Pancreas Flashcards
1
Q
Alpha cells secrete?
A
- Glucagon!
2
Q
Delta cells secrete?
A
- Somatostatin!
3
Q
Proinsulin splits into the following 2 enzymes ?
A
- Insulin
3. C-peptide
4
Q
Second messenger involved in insulin receptor ?
A
- Tyrosine kinase
5
Q
How is glucose taken up by tissues ?
A
Facilitated transport.
6
Q
What are some insulin-dependent tissues?
A
- Adipose tissue
- Muscle (resting)
- Liver
7
Q
What are some insulin INDEPENDENT tissues?
A
- Brain
- RBC
- Intestine
- Kidney
- Liver?
- Placenta
- Sperm
8
Q
Is insulin a catabolic or anabolic hormone?
A
- Anabolic (⬆️protein synthesis)
9
Q
Insulin effect on carbohydrates?
A
- ⬇️Glucose levels
2. Glycogensis ⬆️
10
Q
Insulin effect on protein metabolism ?
A
- ⬆️Protein synthesis
11
Q
Insulin effect on lipid metabolism?
A
- ⬇️Lipolysis
12
Q
Insulin effect on K+ levels?
A
- ⬆️Na+K+ ATPase
2. ⬇️K+ levels
13
Q
How are ATP-K+ gated channels closed?
A
- Glucose enters the cell
- ⬆️Glycolysis
- ⬆️ATP
- ⬆️Intracellular K+
- Depolarization
- ⬆️Voltage Gated Ca+ channels
- ⬆️Ca+ levels
- ⬆️ Insulin Exocitosis
14
Q
Mechanism of action of Sulfonylureas?
A
- Block ATP-sensitive K+ Channels
2. ⬆️ Insulin release!!
15
Q
Name the Incretins?
A
- Glucagon-Like Peptide (GLP)
2. Glucose Insulinotropic Peptide (GIP)
