Aldosterone Hormone Flashcards
Aldosterone main site of action in the kidneys?
- Collecting ducts
Aldosterone Mechanism of action in Principal Cells of the collecting duct?
- ⬆️Na K ATPase
- ⬆️Na+ reabsorption
- ⬆️K+ secretion
Aldosterone Mechanism of action in Intercalated Cells of the collecting duct?
- ⬆️H-ATPase
- ⬆️H+ secretion
- ⬆️HCO3- reabsorption
Change in pH with ⬆️Aldosterone ?
- ⬆️pH Metabolic Alkalosis
Changes in pH with ⬇️Aldosterone ?
- ⬇️pH Metabolic Acidosis
What are the short term regulators of Aldosterone ?
- Angiotensin II
2. K+ levels
Long term regulator of Aldosterone?
- RAAS
Afferent arteriole ⬆️ in volume leads to —— in Aldosterone levels?
⬇️Aldosterone
Afferent arteriole ⬇️ in volume leads to —— in Aldosterone levels?
- ⬇️Aldosterone
An ⬆️ in Na+ levels in Macula Densa leads to ___ in Aldosterone levels?
- ⬇️RAAS and ⬇️Aldosterone
An ⬇️ in Na+ levels in Macula Densa leads to ___ in Aldosterone levels?
- ⬆️RAAS and ⬆️Aldosterone
Other name for Primary Hyperaldosteronism?
- Conn’s Syndrome
Primary Hyperaldosteronism Etiology?
- Adrenal Adenoma
2. Bilateral Adrenal Hyperplasia
Main signs for Primary Hyperaldosteronism?
- Hypertension
- Hypokalemia
- Metabolic Alkalosis
- ⬇️Renin
Secondary Hyperaldosteronism main Etiology?
—HYPERTENSION—
- Bilateral Renal Stenosis
- Bilateral Renal Fibromuscular Hyperplasia
—HYPOTENSION—
- CHF
- Nephrotic Syndrome
- Hepatic Cirrhosis
BOTH HAVE ⬆️Renin