Growth Hormone

Question 1

Hormones involved in Intrauterine growth?

Answer 1

1. GH
2. IGF II (early gestation)
3. IGF I (late gestation)
4. Insulin

Question 2

Most important hormones in postnatal growth?

Answer 2

1. GH
2. Thyroid Hormones (permissive)
3. Insulin

Question 3

What hormone deficiency stunts growth the most?

Answer 3

1. Thyroid hormone > GH

Question 4

Drug that stunts growth ?

Answer 4

1. Glucocorticoids

Question 5

What are the 2 clinical presentations of Prepubertal GH deficiency?

Answer 5

1. Dwarfism

2. Laron Syndrome

Question 6

Laron syndrome pathophysiology?

Answer 6

1. ⬆️GH resistance

2. ⬇️IGF-1

Question 7

GH deficiency symptoms aside from short stature?

Answer 7

1. Small penis

2. Hypoglycemia

Question 8

GH direct anabolic effect?

Answer 8

1. ⬆️A.A uptake —> ⬆️protein synthesis

Question 9

Indirect GH anabolic effects?

Answer 9

1. ⬆️IGF
2. ⬆️Chondrogenesis
3. ⬆️Muscle mass

Question 10

Direct GH catabolic effects?

Answer 10

1. ⬆️Glycogenolysis—> ⬆️Glucose levels

2. ⬆️ Lipolysis

Question 11

How does GH induce ⬆️ of IGF’s?

Answer 11

1. Stimulating Skeletal Muscle and Liver.

Question 12

This hormone inhibits GH release?

Answer 12

Somatostatin

Question 13

GH achieves its peak secretion at these stages of sleep?

Answer 13

1. III/IV

Question 14

How to diagnose Acromegaly, aside from clinical signs and MRI?

Answer 14

1. ⬆️IGF levels

2. Failure to ⬇️ suppress GH with Glucose tolerance test