Pancreas Flashcards
Part of pancreas that secretes digestive enzymes and bicarbonate
head
Part of pancreas that secretes insulin and glucagon
body
Part of pancreas that produces digestive enzymes and insulin
tail
Fecal elastase in chronic pancreatitis
<200
Pancrelipase (Creon) dose (pancreatic insufficiency, chronic pancreatitis)
10,000 - 25,000 lipase units/meal
Cells that make up the exocrine pancreas
acinar cells
Cells that make up the endocrine pancreas
islets of Langerhans
Hormones secreted by the islets of Langerhans (3)
insulin, glucagon, somatostatin
Gene testing for suspected hereditary pancreatitis (2)
CFTR gene (cystic fibrosis)
PRSS1 (hereditary pancreatitis)
Most common cause of hereditary pancreatitis
PRSS1 gene mutation
PRSS1 mutation inheritance pattern
autosomal dominant
Chemo options for pancreatic cancer (2)
FOLFIRINOX
gemcitabine
Lipase level diagnostic for pancreatitis (factor of ULN and rough number)
3x ULN, ~400 (ULN is around 140)
Stool elastase diagnostic for pancreatic insufficiency
< 200 ug/g
Early fluid resuscitation amount for pancreatitis
20-30 mL/kg
Ranson’s criteria (initial) (5)
age > 55
WBC > 16,000
BG > 200
LDH > 350
AST > 250
Indications for drainage of a pancreatic pseudocyst (3)
1) > 6 cm
2) symptomatic
3) or infected
Preferred fluid and rate for acute pancreatitis treatment
LR @ 250-500/hr
Fecal elastase indicative of exocrine insufficiency
< 200
Most common portion involved w/ pancreatic cancer
head
Most common portion involved w/ pancreatitis
head
Medication that reduces pancreatic secretions
octreotide
