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Gastroenterology > Medication & Treatment > Flashcards

Medication & Treatment Flashcards

1
Q

Monitoring needed in long-term PPI use (3)

A

magnesium
calcium
B12

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2
Q

Long-term risks of PPIs (2)

A

osteoporosis
renal dysfunction

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3
Q

Metoclopramide dose (gastroparesis)

A

10-15 mg 3-4 times daily

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4
Q

Botox dose (achalasia, esophageal spasms)

A

100-200 units at LES

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5
Q

Dantrolene dose (diffuse esophageal spasm)

A

25 mg qday, increase as needed

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6
Q

Lansoprazole brand name

A

prevacid

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7
Q

Lansoprazole (prevacid) dose

A

15-30 mg daily

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8
Q

Potential drug interaction with pantoprazole (protonix)

A

clopidogrel

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9
Q

Mesalamine brand names (2)

A

asacol
lialda

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10
Q

Mesalamine dose (UC, Crohn’s)

A

2.4-4.8 g daily

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11
Q

Infliximab brand name

A

remicade

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12
Q

Infliximab dose (UC, Crohn’s)

A

5-10 mg/kg q8 weeks

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13
Q

Adalimumab brand name

A

humira

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14
Q

Adalimumab dose (UC, Crohn’s)

A

160 mg then 80 mg

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15
Q

Vedolizumab brand name

A

entyvio

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16
Q

Vedolizumab dose (UC, Crohn’s)

A

300 mg q4-8 weeks

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17
Q

Ustekinumab brand name

A

stelara

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18
Q

Ustekinumab dose (UC, Crohn’s)

A

130 mg initial then 90 mg q8-12 weeks

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19
Q

Linaclotide brand name

A

linzess

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20
Q

Linaclotide dose (IBS-C)

A

145 mcg daily

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21
Q

Lubiprostone brand name

A

amitiza

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22
Q

Lubiprostone dose (IBS-C, chronic idiopathic constipation)

A

8-24 mcg BID

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23
Q

Rifaximin brand name

A

xifaxan

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24
Q

Rifaximin dose (IBS-D, hepatic encephalopathy)

A

550 mg BID for 14 days

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25
Q

Budesonide brand name (2)

A

entocort
uceris

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26
Q

Budesonide dose (UC, Crohn’s)

A

9 mg daily

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27
Q

Lab monitoring needed for long-term budesonide treatment

A

bone density

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28
Q

Prednisone brand name

A

deltasone

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29
Q

Prednisone dose (severe IBD, autoimmune hepatitis)

A

40-60 mg daily

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30
Q

Ursodiol brand name

A

actigall

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31
Q

Ursodiol dose (PBC)

A

300 mg BID

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32
Q

Promethazine brand name

A

phenergan

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33
Q

Promethazine dose (N/V)

A

25 mg q4-6 hours prn

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34
Q

Loperamide dosing

A

2-4 mg prn

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35
Q

Maximum daily loperamide dose

A

16 mg

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36
Q

Hyoscyamine brand name

A

levsin

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37
Q

Hyoscyamine dose (IBS, abdominal cramps)

A

0.125-0.25 mg q4h prn

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38
Q

Dicyclomine brand name

A

bentyl

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39
Q

Dicyclomine dose (IBS - cramping)

A

10-20 mg QID

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40
Q

Metronidazole dose (C. diff, intra-abdominal infections)

A

500 mg TID for 10-14 days

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41
Q

Ciprofloxacin dose (infectious diarrhea)

A

500 mg BID for 7-14 days

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42
Q

Plecanatide brand name

A

trulance

43
Q

Plecanatide dose (IBS-C, chronic idiopathic constipation)

A

3 mg daily

44
Q

Alosetron brand name

A

lotronex

45
Q

Alosetron dose (severe IBS-D in women)

A

0.5-1 mg BID

46
Q

Risk associated with alosetron

A

ischemic colitis

47
Q

Tacrolimus brand name

A

prograf

48
Q

Tacrolimus dose (refractory IBD)

A

0.05-0.2 mg/kg daily

49
Q

Azathioprine brand name

A

imuran

50
Q

Azathioprine dose (IBD, autoimmune hepatitis)

A

1-2.5 mg/kg daily

51
Q

6-mercaptopurine brand name

A

purinethol

52
Q

6-mercaptopurine dose (IBD - maintenance only)

A

1-1.5 mg/kg daily

53
Q

Eluxadoline brand name

A

viberzi

54
Q

Eluxadoline dose (IBS-D)

A

75-100 mg BID

55
Q

Bezlotoxumab (zinplava) dose (prevention of C. diff recurrence)

A

10 mg/kg IV once

56
Q

Erythromycin dose (gastroparesis)

A

250-500 mg TID

57
Q

Octreotide dose (variceal bleed, neuroendocrine tumor)

A

50-100 mcg SC BID

58
Q

Methotrexate dose (Crohn’s)

A

15-25 mg weekly

59
Q

Balsalazide brand name

A

colazal

60
Q

Balsalazide dose (UC)

A

2.25 g TID

61
Q

Major benefit of balsalazide

A

targeted colonic release

62
Q

Natalizumab (tysabri) dose (refractory Crohn’s)

A

300 mg q4 weeks

63
Q

Infliximab (remicade) MOA

A

TNF-alpha inhibitor

64
Q

Adalimumab (humira) MOA

A

TNF-alpha inhibitor

65
Q

Vedolizumab (entyvio) MOA

A

integrin inhibitor

66
Q

Ustekinumab (stelara) MOA

A

IL-12 and IL-23 inhibitor

67
Q

Tofacitinib brand name

A

xeljanz

68
Q

Tofacitinib (xeljanz) MOA

A

janus kinase inhibitor

69
Q

Tofacitinib dose (moderate to severe UC)

A

xeljanz: 10 mg BID for 8 weeks, then 5 mg
xeljanz XR: 11 mg once daily

70
Q

Monitoring required for tofacitinib (xeljanz)

A

monitoring for thrombosis

71
Q

PO regimen for diverticulitis

A

500 mg cipro BID + 500 mg metronidazole TID x 7-10 days

72
Q

Non-severe C. diff treatment

A

vancomycin 125mg QID x 10 days

73
Q

Severe C. diff treatment

A

vancomycin 500 mg QID + IV metronidazole

74
Q

Microscopic colitis treatment

A

budesonide 9 mg/day for 6-8 weeks

75
Q

Amoxicillin dose (H. pylori eradication)

A

1000 mg BID

76
Q

Sucralfate dose

A

1 g QID

77
Q

Metoclopramide dose

A

10 mg TID

78
Q

Giardia treatment

A

metronidazole 250-500 mg TID for 5-7 days

79
Q

Amebiasis treatment

A

1) metronidazole 750 mg TID for 7-10 days then
2) iodoquinol 650 mg TID for 20 days

80
Q

PPI and its dose for Zollinger-Ellison Syndrome

A

omeprazole 60 mg BID

81
Q

H. pylori quadruple therapy

A

1) PPI BID (omeprazole 20mg, lansoprazole 30mg, pantoprazole 40mg, esomeprazole 40mg)
2) bismuth subsalicylate 524mg QID
3) antibiotic #1 (tetracycline 500mg QID)
4) antibiotic #2 (metronidazole 500mg TID or clarithromycin 500mg BID)

82
Q

Docusate MOA

A

surfactant

83
Q

Miralax MOA

A

osmotic laxative

84
Q

PPI drip rate in upper GI bleed

A

8 mg/hr

85
Q

Gut-specific biologic

A

vedolizumab (entyvio)

86
Q

Common screening not needed for vedolizumab (entyvio)

A

TB

87
Q

Upadacitinib brand name

A

rinvoq

88
Q

Upadacitinib (rinvoq) MOA

A

JAK-1 selective inhibitor

89
Q

UC specific biologics (2)

A

tofacitinib (xeljanz)
upadacitinib (rinvoq)

90
Q

Risankizumab brand name

A

skyrizi

91
Q

Risankizumab (skyrizi) MOA

A

IL-23 (p19 subunit) inhibitor

92
Q

Biologic that is Crohn’s specific

A

risankizumab (skyrizi)

93
Q

Most sedating TCA

A

amitriptyline

94
Q

TCA for IBS w/ best side-effect profile

A

desipramine

95
Q

Best TCA for IBS-C

A

desipramine

96
Q

PPI w/ best absorption

A

esomeprazole

97
Q

Upadacitinib (rinvoq) MOA

A

selective JAK1 inhibitor

98
Q

Risankizumab (skyrizi) MOA

A

selective IL-23 inhibitor

99
Q

Tofacitinib (xeljanz) MOA

A

JAK1/3 inhibitor

100
Q

Medication particularly helpful for postprandial abdominal pain

A

dicyclomine

101
Q

Three most common medication classes for causing microscopic colitis

A

NSAIDs
PPIs
SSRIs

102
Q

IBS-D medication only indicated in women

A

alosetron (lotronex)

103
Q

Post-ERCP indomethacin dose

A

100 mg

Gastroenterology (15 decks)

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