Pain Management Flashcards

1
Q

define somatic pain

A

localized aching or throbbing

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2
Q

define visceral pain

A

pain in organs

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3
Q

define central pain

A

non-nerve related, pain that cannot be identified physically

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4
Q

fibromyalgia is categorized under what type of pain?

A

central pain

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5
Q

what is the purpose of the JCAHO accreditation?

A

inform patients rights to pain assessment and management

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6
Q

define nociception

A

sensation of pain

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7
Q

define proprioception

A

perception of the body/placement of limbs

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8
Q

define allodynia or hyperalgesia

A

hypersensitivity and pain response to normal tactile stimuli. such as a sunburn

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9
Q

define analgesia

A

blocking only of nociception

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10
Q

define anesthesia

A

blocking all sensation

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11
Q

where does initiation of pain occur?

A

from stimulus in periphery

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12
Q

where does transmission of pain occur?

A

in spinal cord

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13
Q

where does perception of pain occur?

A

in brain

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14
Q

where does reaction of pain occur?
what is the reaction?

A

in brainstem-reflex motor
inhibition or sensitization outputs

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15
Q

what do Mu opioid receptors do on pre-synaptic neuron?

A

blunt pain and block calcium channels to decrease NT release

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16
Q

Mu opioid receptors are inhibitory or non-inhibitory?
G-protein coupled or non-G protein coupled

A

inhibitory and G-protein couplred

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17
Q

what do the free nerve endings in the dermis of skin sense?

A

light touch, pressure, or pain perception

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18
Q

where is the first stop once a pain signal is initiated?

A

the spinal cord dorsal horn

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19
Q

what do Mu opioid receptors do on post-synaptic neuron?

A

cause hyperpolarization by increasing k+ out of neuron and desensitize

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20
Q

what part of the brain is the primary site for distribution of pain signals?

A

thalamus

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21
Q

projections to _____________ localize pain

A

somatosensory cortex

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22
Q

projections to ________ and _______ shape emotional and cognitive responses and reactions

A

prefrontal cortex, limbic areas

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23
Q

which parts of the brain carry out descending modulation of pain?

A

rostral ventromedial medulla
periaqueductal gray

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24
Q

which parts of the brain influence motivational information (to prevent future pain)?

A

Ventral tegmental area
Thalamus

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25
which parts of the brain process your emotional response to pain?
Anterior cingulate cortex Insula Nucleus accumbens Amygdala Parabrachial nucleus
26
how do opioids interact with GABA?
they inhibit GABA inhibition of descending inhibitory pathways Explanation: they block the inhibition caused by GABA in descending inhibitory pathways to allow activation of the descending inhibitory pathways to block pain
27
which two NTs do descending inhibitory pathways utilize to activate inhibitory interneurons in the dorsal horn? Given what these two NTs are, what drug class has analgesic action?
5-HT and NE SNRIs
28
what are the 3 sites of opioid action? (PAG, RVM, and DH)
periaqueductal gray, rostral ventromedial medulla, and dorsal horn
29
define a narcotic
anything that dulls the senses, relieves pain and induces sleep
30
define opioid
anything that binds to opioid receptors
31
preproopiomelanocortin, preproenkephalin, prepordynorphin, and preproorphanin are all classified as?
opioid receptor agonists
32
Beta-Endorphin, Met-enkephalin, and Leu-enkephalin all have high affinity for which types of opioid receptors?
mu and delta
33
dynorphin A and B have high affinity for which opioid receptor type?
kappa
34
what effects would you expect from drugs that target mu opioid receptors?
analgesia, sedation, euphoria, respiratory depression, constipation and dependence
35
what effects would you expect from drugs that target delta opioid receptors?
mild analgesia, less respiratory depression, less constipation (compared to mu)
36
what effects would you expect from drugs that target kappa opioid receptors?
analgesia, less respiratory depression, dysphoria, less dependence, minimal constipation (compared to mu)
37
how does respiratory depression occur when using CNS depressants?
The pons region of the brain has decreased sensitivity to pCO2 and therefore you don't realize you need more oxygen in the brain
38
how do opioids have antitussive effects?
inhibits cough center in the medulla
39
why do opioids cause nausea and vomiting?
they stimulate the chemoreceptor trigger zone
40
opioids cause miosis or mitosis?
miosis
41
T/F opioids block the baroreflex
false, they blunt it, not completely block
42
opioid effect on stomach:
decreased secretions and motility
43
opioid effect on intestines:
decrease propulsion and water secretion
44
opioid effect on sphincters:
contraction of smooth muscle
45
what is the mechanism behind opioids decreasing stomach secretion/water secretion?
they decrease cAMP levels which are important for water secretion which is important for gut mobility
46
what is the mechanism behind opioids causing sphincter smooth muscle contraction?
decreasing cAMP levels causes contraction of smooth muscle
47
opioid effect on urinary tract:
contraction of smooth muscle - urinary retention
48
opioid effect on uterine smooth muscle:
prolongation of labor
49
opioid effect on bronchiole smooth muscle:
constriction, may be problematic in asthma
50
opioid effect on vascular smooth muscle:
hypotension from release of histamine
51
opioid effect on basal metabolic rate and temperature:
modest decrease
52
opioid effect on immune system:
modest immunosuppression
53
opioid effect on mast cells:
histamine release
54
opioid effect on pituitary:
possible increase in prolactin and growth hormone
55
opioids can cause hypogonadism which is a decrease in hormones such as estradiol and testosterone. what SEs would you expect?
decreased libido, menstrual irregularity
56
what are the diagnostic triad signs of acute overdose of opioids?
pinpoint pupils, respiratory depression, and coma
57
what is the indication of opioid-induced hyperalgesia?
increasing dose without relief
58
You can build tolerance to opioid SEs except for which two SEs?
constipation and miosis
59
why can NSAIDs, SNRIs, acetaminophen, local anesthetics, and alpha 2 agonists be helpful as combo therapy with opioids?
they reduce pain at lower opioid doses so you can dose less opioid
60
list all of the withdrawal symptoms from opioids: (T T S H P P I M D L N V H I)
tachypnea (rapid breathing) tachycardia sweating hypertension piloerection pupillary dilation and photophobia insomnia myalgia diarrhea lacrimation nausea vomiting hyperthermia irratability
61
what drug can be used to treat the autonomic hyperactivity and anxiety from opioid withdrawal?
clonidine
62
what drugs can be used to treat myalgia from opioid withdrawal?
NSAIDs
63
what drug can be used to treat diarrhea from opioid withdrawal?
loperamide
64
what is the longest acting opioid agonist? what is it used for?
methadone: pain management of opioid use disorder as maintenance therapy
65
what drug has a toxic metabolite and should be avoided?
meperidine
66
codeine must be metabolized to ____ for efficacy, many people are _____ metabolizers
morphine, poor
67
TRV130 has biased agonism, explain what this means
mu opioid receptors have two components - G protein and Beta-arrestin. G protein is normally blocked by Beta-arrestin which decreases respiration and GI function. TRV130 blocks Beta-arrestin, allowing G protein to stay active which will increase analgesic effects
68
what drug formulations does Naloxone come in?
IM, IV, or nasal
69
what is Naltrexone used for?
to treat opioid use disorder and alcoholism
70
How do Naloxegol, Methylnatrexone, Naldemedine, and Alvimopan work for treating opioid-induced constipation?
they are opioid antagonists that have no CNS effects, so they can block opioid stimulation in periphery w/o blocking pain relief
71
why would we prescribe oxycodone + naloxone, buprenorphine + naloxone, or pentazoxine + naloxone?
they prevent people from IV injecting opioids => naloxone blocks opioid actions if injected, but not if taken orally, so patient has to take med orally to have any pain relief