CNS Stimulants Medchem

Question 1

dextroamphetamine undergoes p450 deamination to what metabolite?

Answer 1

phenyl acetone

Question 2

how does adding an alpha-methyl to adderalls structure effect metabolism?

Answer 2

decreases metabolism

Question 3

what is the only difference between adderall and methamphetamine?
how does this effect the drug?

Answer 3

added a methyl group onto the nitrogen
it increases cns activity and increases abuse potential

Question 4

MDMA is similar to paroxetine in that it is an inhibitor of what route of metabolism?

Answer 4

2D6

Question 5

what is the inactive metabolite of methylphenidate?

Answer 5

ritalinic acid

Question 6

methylphenidate is used as a racemate of?

Answer 6

R,R and S,S

Question 7

what is the active enantiomer (R,R) of methylphenidate?

Answer 7

dexmethylphenidate

Question 8

viloxazine is a strong inhibitor of what route of metabolism?
weak inhibitor of which 2 routes?

Answer 8

1A2
2D6 and 3A4

Question 9

what drugs are metabolized by 1A2?

Answer 9

caffeine
theophylline

Question 10

what drugs are metabolized by MAO?

Answer 10

mescaline

Question 11

which drug is metabolized by 2D6 and 1A2?

Answer 11

MDMA

Question 12

what drugs are metabolized by 2D6?

Answer 12

Atomoxetine
Viloxazine