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0. Step Ib > P450 modulators > Flashcards

P450 modulators Flashcards

Are these inhibitors, inducers, or substrates of P450?

1
Q

Sulfonamides

A

inhibitor

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1
Q

Anesthetics

A

P450 substrate

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1
Q

Theophylline

A

P450 substrate

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2
Q

Alcohol (chronic)

A

inducer

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2
Q

Phenobarbitone/phenobarbitol (barbituates)

A

inducer

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3
Q

Cimetidine

A

inhibitor

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3
Q

Macrolides

A

inhibitor

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5
Q

Grapefruit juice

A

inhibitor

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6
Q

Alcohol (binge drinking)

A

inhibitor

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6
Q

Omeprazole

A

inhibitor

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7
Q

valproate

A

inhibitor

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8
Q

Sulphonylureas

A

inducer

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8
Q

OCPs

A

P450 substrate

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9
Q

Griseofulvin

A

inducer

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10
Q

Mnemonic for P450 Substrates

A

Always, Always, Always, Always Think When Starting Others

Anti-epileptics

Anti-psychotics

Anti-depressants

Anesthetics

Theophylline

Warfarin

Statins

OCP

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12
Q

Warfarin

A

P450 substrate

13
Q

Isoniazid

A

inhibitor

15
Q

Rifampicin

A

inducer

16
Q

Ciprofloxacin

A

inhibitor

16
Q

Ritonavir (protease inhibitor)

A

inhibitor

18
Q

SSRI

A

inhibitor

20
Q

Jullet’s mneomnic for P450 inhibitors

A

A SICCC GRAVE TAG means death

  • Azoles (Metronidazole, Omeprazole, ketoconazole, Fluconazole)
  • SSRIs/Sulfonamides
  • Isoniazid
  • Chloramphenicol
  • Ciprofloxacin
  • Cimetidine
  • Gemfibrozil
  • **Ritonaviar **
  • Alcohol..binge
  • Valproate
  • Erythromycin

​

  • Tripmethoprim
  • Amiodarone
  • Grapefruit juice
21
Q

Trimetoprim

A

inhibitor

22
Q

Anti-psychotics

A

P450 substrate

23
Q

Phenytoin

A

inducer

24
Q

Chloramphenicol

A

inhibitor

25
Q

Anti-depressants

A

P450 substrate

26
Q

Carbemazepines

A

inducer

27
Q

Azole anti-fungals (Ketoconazole, Fluconazole)

A

inhibitor

29
Q

Erythromycin

A

inhibitor

31
Q

Amidarone

A

inhibitor

32
Q

mneomnic for P450 inducers

A

P450 Inducers - CRAP GPS Mode Sucks; induces me to madness

  • Carbamazepines
  • Rifampicin
  • Alcohol (chronic)
  • Phenytoin
  • Griseofulvin
  • Phenobarbital
  • Sulphonylureas
  • Modafinil
  • St Johns wort
33
Q

gemfibrozil

A

inhibitor

34
Q

Anti-epileptic

A

P450 substrate

35
Q

Statins

A

P450 substrate

0. Step Ib (19 decks)

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