P450 modulators Flashcards
Are these inhibitors, inducers, or substrates of P450?
Sulfonamides
inhibitor
Anesthetics
P450 substrate
Theophylline
P450 substrate
Alcohol (chronic)
inducer
Phenobarbitone/phenobarbitol (barbituates)
inducer
Cimetidine
inhibitor
Macrolides
inhibitor
Grapefruit juice
inhibitor
Alcohol (binge drinking)
inhibitor
Omeprazole
inhibitor
valproate
inhibitor
Sulphonylureas
inducer
OCPs
P450 substrate
Griseofulvin
inducer
Mnemonic for P450 Substrates
Always, Always, Always, Always Think When Starting Others
Anti-epileptics
Anti-psychotics
Anti-depressants
Anesthetics
Theophylline
Warfarin
Statins
OCP
Warfarin
P450 substrate
Isoniazid
inhibitor
Rifampicin
inducer
Ciprofloxacin
inhibitor
Ritonavir (protease inhibitor)
inhibitor
SSRI
inhibitor
Jullet’s mneomnic for P450 inhibitors
A SICCC GRAVE TAG means death
- Azoles (Metronidazole, Omeprazole, ketoconazole, Fluconazole)
- SSRIs/Sulfonamides
- Isoniazid
- Chloramphenicol
- Ciprofloxacin
- Cimetidine
- Gemfibrozil
- **Ritonaviar **
- Alcohol..binge
- Valproate
- Erythromycin
- Tripmethoprim
- Amiodarone
- Grapefruit juice
Trimetoprim
inhibitor
Anti-psychotics
P450 substrate
Phenytoin
inducer
Chloramphenicol
inhibitor
Anti-depressants
P450 substrate
Carbemazepines
inducer
Azole anti-fungals (Ketoconazole, Fluconazole)
inhibitor
Erythromycin
inhibitor
Amidarone
inhibitor
mneomnic for P450 inducers
P450 Inducers - CRAP GPS Mode Sucks; induces me to madness
- Carbamazepines
- Rifampicin
- Alcohol (chronic)
- Phenytoin
- Griseofulvin
- Phenobarbital
- Sulphonylureas
- Modafinil
- St Johns wort
gemfibrozil
inhibitor
Anti-epileptic
P450 substrate
Statins
P450 substrate