autonomic receptors

Question 1

α1

Answer 1

VSM - vasoconstriction

GI/GU - constriction

Eye - mydriasis, aka dilation (constriction of pupillary dilator muscle!)

[theme = constriction]

Question 2

α2

Answer 2

nerve terminals -> decr. NT release

platelets - increase aggregation

Question 3

ß1

Answer 3

heart - increase HR, contractility

kidneys - increase renin release

[ß1: ONE heart ONE love to get your HR up]

Question 4

ß2

Answer 4

lungs - bronchodilation [ß2: TWO lungs]

VSM - vasodilation

Uterus - relaxation (tocolysis)

[ex: Terbutaline: ß2 agonist relaxes uterine contractions -> stops premature labor]

Question 5

D1

Answer 5

renal, splanchnic, and mesenteric BV smooth muscles -> vasodilation (increases renal + splanchnic blood flow)

[Incr RBF]

D for dilation

Question 6

D2

Answer 6

nerve terminals & nT release in CNS

Question 7

V1

Answer 7

VSM = increase contraction

ex: vasopressin

Question 8

V2

Answer 8

renal CD - increase H2O uptake

[V2: 2 kidneys]

Question 9

M1

Answer 9

CNS

enteric NS

Question 10

M2

Answer 10

heart - decrease HR/contractility

[opposes ß1 effects]

Question 11

M3

Answer 11

GI - increase peristalsis

GU - increase bladder contraction

lungs - bronchoconstriction

eyes - pupil sphincter

[M3 -> messy: tears, urine, sputum. H1 makes more mucous though]

Question 12

H1

Answer 12

increase mucous production in nose, bronchus

increase vascular permeability

increase contraction of bronchioles

pain

[H1 blocker = antihistamines like diphenhydramine/Benadryl or Loratidine]

Question 13

H2

Answer 13

increase gastric acid production

[H2 blocker: symetidine]

Question 14

pupils - constrict

Answer 14

M3 (or α1 blockade)

Question 15

pupils - dilate (mydriasis)

Answer 15

α1 (or M3 blockade)

Question 16

VSM - dilate

Answer 16

ß2 (redirect flow towards specific areas during sympathetic activation)

Question 17

VSM - constrict

Answer 17

α1, V1 (redirect flow away from specific aways during sympathetic activation)

Question 18

heart - decrease HR/contractility

Answer 18

M2

Question 19

heart - increase HR/contractility

Answer 19

ß1

Question 20

lungs - bronchoconstriction

Answer 20

M3

Question 21

lungs - bronchodilation

Answer 21

ß2

Question 22

GI - increase peristalsis

Answer 22

M3

Question 23

GI - decrease peristalsis

Answer 23

α1

Question 24

GU - increase function

Answer 24

M3

Question 25

GU - decrease function

Answer 25

α1

Question 26

uterus relaxation

Answer 26

ß2

Question 27

which receptor types use the Gq pathway? very generally what does this lead to?

Answer 27

H1, α1, V1, M1, M3 "HAVe 1 M&M." or "HAVe 1,3 Chocolate M&Ms" since pathway uses Phospholipase C, Protein Kinase C, increases Ca, and uses IP3 --\>leads to smooth muscle contraction

Question 28

which receptor types use the Gs pathway? generally leads to what?

Answer 28

ß1, ß2, D1, H2, V2 pathway uses Adenylyl Cyclase, ATP, cAMP, PKA. --\> increases intracellular Ca in heart

Question 29

which receptor types use the Gi pathway? generally leads to what?

Answer 29

M2, α2, D2 "MAD 2s" these BLOCK the pathway that uses Adenylyl Cyclase, ATP, cAMP, PKA. --\> relaxes smooth muscle

Question 30

effect of understimulating α1?

Answer 30

orthostatic hypotension

Question 31

effect of understimulating α2?

Answer 31

Release of norepinephrine Release of insulin

Question 32

effect of understimulating ß1?

Answer 32

bradycardia decr contractility, slower conduction

Question 33

effect of understimulating ß2?

Answer 33

vasoconstriction bronchoconstriction