autonomic receptors Flashcards

1
Q

α1

A

VSM - vasoconstriction

GI/GU - constriction

Eye - mydriasis, aka dilation (constriction of pupillary dilator muscle!)

[theme = constriction]

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2
Q

α2

A

nerve terminals -> decr. NT release

platelets - increase aggregation

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3
Q

ß1

A

heart - increase HR, contractility

kidneys - increase renin release

[ß1: ONE heart ONE love to get your HR up]

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4
Q

ß2

A

lungs - bronchodilation [ß2: TWO lungs]

VSM - vasodilation

Uterus - relaxation (tocolysis)

[ex: Terbutaline: ß2 agonist relaxes uterine contractions -> stops premature labor]

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5
Q

D1

A

renal, splanchnic, and mesenteric BV smooth muscles -> vasodilation (increases renal + splanchnic blood flow)

[Incr RBF]

D for dilation

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6
Q

D2

A

nerve terminals & nT release in CNS

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7
Q

V1

A

VSM = increase contraction

ex: vasopressin

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8
Q

V2

A

renal CD - increase H2O uptake

[V2: 2 kidneys]

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9
Q

M1

A

CNS

enteric NS

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10
Q

M2

A

heart - decrease HR/contractility

[opposes ß1 effects]

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11
Q

M3

A

GI - increase peristalsis

GU - increase bladder contraction

lungs - bronchoconstriction

eyes - pupil sphincter

[M3 -> messy: tears, urine, sputum. H1 makes more mucous though]

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12
Q

H1

A

increase mucous production in nose, bronchus

increase vascular permeability

increase contraction of bronchioles

pain

[H1 blocker = antihistamines like diphenhydramine/Benadryl or Loratidine]

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13
Q

H2

A

increase gastric acid production

[H2 blocker: symetidine]

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14
Q

pupils - constrict

A

M3 (or α1 blockade)

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15
Q

pupils - dilate (mydriasis)

A

α1 (or M3 blockade)

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16
Q

VSM - dilate

A

ß2 (redirect flow towards specific areas during sympathetic activation)

17
Q

VSM - constrict

A

α1, V1 (redirect flow away from specific aways during sympathetic activation)

18
Q

heart - decrease HR/contractility

A

M2

19
Q

heart - increase HR/contractility

A

ß1

20
Q

lungs - bronchoconstriction

A

M3

21
Q

lungs - bronchodilation

A

ß2

22
Q

GI - increase peristalsis

A

M3

23
Q

GI - decrease peristalsis

A

α1

24
Q

GU - increase function

A

M3

25
Q

GU - decrease function

A

α1

26
Q

uterus relaxation

A

ß2

27
Q

which receptor types use the Gq pathway? very generally what does this lead to?

A

H1, α1, V1, M1, M3 “HAVe 1 M&M.”

or “HAVe 1,3 Chocolate M&Ms” since pathway uses Phospholipase C, Protein Kinase C, increases Ca, and uses IP3

–>leads to smooth muscle contraction

28
Q

which receptor types use the Gs pathway? generally leads to what?

A

ß1, ß2, D1, H2, V2

pathway uses Adenylyl Cyclase, ATP, cAMP, PKA.

–> increases intracellular Ca in heart

29
Q

which receptor types use the Gi pathway? generally leads to what?

A

M2, α2, D2

“MAD 2s”

these BLOCK the pathway that uses Adenylyl Cyclase, ATP, cAMP, PKA.

–> relaxes smooth muscle

30
Q

effect of understimulating α1?

A

orthostatic hypotension

31
Q

effect of understimulating α2?

A

Release of norepinephrine

Release of insulin

32
Q

effect of understimulating ß1?

A

bradycardia

decr contractility, slower conduction

33
Q

effect of understimulating ß2?

A

vasoconstriction

bronchoconstriction