P450 Inhibitor, Inducer, or Substrate Flashcards

1
Q

Where are P450 enzymes located?

A

Liver…and small intestine

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2
Q

Chronic Alcohol use

A

Inducer

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3
Q

OCPs

A

Substrates

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4
Q

Macrolides

A

Inhibitor (except azithromycin)

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5
Q

Quinidine

A

Inhibitor

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6
Q

St. John’s Wart

A

Inducer

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7
Q

Phenytoin

A

Inducer

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8
Q

Theophylline

A

Substrate

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9
Q

Acute Alcohol Use

A

Inhibitor

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10
Q

Ritonavir

A

Inhibitor

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11
Q

Phenobarbital

A

Inducer

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12
Q

Warfarin

A

Substrate

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13
Q

Amiodarone

A

Inhibitor

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14
Q

Cimetidine

A

Inhibitor

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15
Q

Nevirapine

A

Inducer

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16
Q

Ketoconazole

A

Inhibitor

17
Q

Sulfonamides

A

Inhibitor

18
Q

Izoniazid

A

Inhibitor

19
Q

Rifampin

A

Inducer

20
Q

Griseofulvin

A

Inducer

21
Q

Grapefruit juice

A

Inhibitor

22
Q

Carbamazepine

A

Inducer

23
Q

Barbituates

A

Inducer

24
Q

Antiepileptics

A

Substrates