Oncogenes (gene/gene product/associated tumor)

Question 1

Oncogenes

Answer 1

Gain of function leading to increased cancer risk. Need damage to only 1 allele.

Question 2

BCR-ABL

Answer 2

GENE PRODUCT: Tyrosine Kinase.

ASSOCIATED TUMOR: CML, ALL

Question 3

BCL-2

Answer 3

GENE PRODUCT: antiapoptotic molecule (inhibits apoptosis)

ASSOCIATED TUMOR: Follicular and undifferentiated lymphoma

Question 4

BRAF

Answer 4

GENE PRODUCT: serine/threonine kinase

ASSOCIATED TUMOR: melanoma, non-hodgkin lymphoma

Question 5

c-kit

Answer 5

GENE PRODUCT: cytokine receptor

ASSOCIATED TUMOR: gastrointestinal stromal tumor (GIST)

Question 6

c-myc

Answer 6

GENE PRODUCT: transcription factor

ASSOCIATED TUMOR: Burkitt lymphoma

Question 7

HER2/neu (c-erbB2)

Answer 7

GENE PRODUCT: tyrosine kinase

ASSOCIATED TUMOR: breast, ovarian, and gastric carcinoma

Question 8

L-myc

Answer 8

GENE PRODUCT: transcription factor

ASSOCIATED TUMOR: lung tumor

Question 9

N-myc

Answer 9

GENE PRODUCT: Transcription factor

ASSOCIATED TUMOR: neuroblastoma

Question 10

RAS

Answer 10

GENE PRODUCT: GTPase

ASSOCIATED TUMOR: colon cancer, lung cancer, pancreatic cancer

Question 11

RET

Answer 11

GENE PRODUCT: tyrosine kinase

ASSOCIATED TUMOR: MEN 2A and 2B, medullary thyroid cancer