Autoantibodies and associated disorders Flashcards

1
Q

Anti-ACh receptor

A

Myasthenia gravis

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2
Q

Anti-basement membrane

A

Good pasture syndrome

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3
Q

anticardiolipin, lupus anticoagulant

A

SLE, antiphospholipid

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4
Q

anticentromere

A

limited scelroderma (CREST syndrome)

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5
Q

Anti-desmosome (anti-desmoglein)

A

Pemphigus vulgaris

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6
Q

Anti-dsDNA, anti-smith

A

SLE

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7
Q

anti-glutamic acid decarboxylase (GAD-65)

A

Type 1 diabetes mellitus

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8
Q

antihemidesmosome

A

bullous pemphigoid

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9
Q

anti-histone

A

drug-induced lupus

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10
Q

Anti-Jo-1, anti-SRP, anti-Mi-2

A

polymyositis, dermatomyositis

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11
Q

antimicrosomal, antithyroglobulin

A

hashimoto thyroiditis

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12
Q

antimitochondrial

A

primary biliary cirrhosis

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13
Q

antinuclear antibodies

A

SLE, nonspecific

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14
Q

antiparietal cells

A

pernicious anemia

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15
Q

anti-scl-70 (anti-DNA topoisomerase I)

A

scleroderma (diffuse)

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16
Q

anti-smooth muscle

A

autoimmune hepatitis

17
Q

anti-SSA, anti-SSB (anti-Ro, anti-La)

A

sjogren syndrome

18
Q

Anti-TSH receptor

A

graves disease

19
Q

anti-U1 RNP (ribonucleoprotein)

A

mixed connective tissue disease

20
Q

IgA anti-endomysial, IgA anti-tissue transglutaminase

A

celiac disease

21
Q

MPO-ANCA/p-ANCA

A

microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (churg-strauss syndrome)

22
Q

PR3-ANCA/c-ANCA

A

granulomatosis with polyangiitis (wegener)

23
Q

Rheumatoid factor (IgM antibody that targets IgG Fc region), anti-CCP (more specific)

A

Rheumatoid arthritis