P450 enzyme system Flashcards
1
Q
Effects often appear more rapidly after exposure to a P450 enxyme inhibitor drug. TRUE/FALSE?
A
TRUE
need prolonged exposure to enzyme inducing drug to see effects
2
Q
Inducing Drugs
A
- Antiepileptics: phenytoin, carbamazepine
- Barbiturates: phenobarbitone
- Rifampicin
- St John’s Wort
- Chronic alcohol intake
- Smoking (affects CYP1A2)
3
Q
Inhibitors
A
- Abx: ciprofloxacin, erythromycin
isoniazid - cimetidine
- omeprazole
- amiodarone
- allopurinol
- antifungals: ketoconazole, fluconazole
- SSRIs: fluoxetine, sertraline
- ritonavir
- sodium valproate
- acute alcohol intake
4
Q
Do drugs inducing the P450 system increased or decrease the INR?
A
Decrease
=> blood more likely to clot
5
Q
Do P450 enzyme inhibitors increase or decrease INR?
A
Increase
=> more likely to bleed
