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MRCP Pharmacology > Management of Hyperlipidaemia > Flashcards

Management of Hyperlipidaemia Flashcards

1
Q

Mechanism of action of statins

A

HMG CoA reductase inhibitors

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2
Q

Adverse effects of statins

A

Myositis
Deranged LFTs

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3
Q

Mechanism of action of ezetimibe

A

Decreases cholesterol absorption in the small intestine

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4
Q

Side effect of ezetimibe

A

Headache

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5
Q

Mechanism of action of nicotinic acid

A

Decreases hepatic VLDL secretion

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6
Q

Side effect of nicotinic acid

A

Flushing, myositis

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7
Q

Mechanism of action of fibrates

A

Agonist of PPAR-alpha
=> lipoprotein lipase expression

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8
Q

Side effects of fibrates

A

Myositis
pruritus
cholestasis

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9
Q

Mechanism of action of cholestyramine

A
  • Decreases bile acid reabsorption in small intestine
  • upregulating amount of cholesterol converted to bile acid
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10
Q

Side effects of cholestyramine

A

GI side-effects

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MRCP Pharmacology (22 decks)

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