Drug-induced side effects Flashcards
Drugs causing impaired glucose tolerance
thiazides
furosemide (less common)
steroids
tacrolimus, ciclosporin
interferon-alpha
nicotinic acid
antipsychotics
beta-blockers (mild)
Drugs causing thrombocytopenia (low platelets, probably immune mediated)
quinine
abciximab
NSAIDs
diuretics: furosemide
antibiotics: penicillins, sulphonamides, rifampicin
anticonvulsants: carbamazepine, valproate
heparin
Drug induced urinary retention
tricyclic antidepressants e.g. amitriptyline
anticholinergics e.g. antipsychotics, antihistamines
opioids
NSAIDs
disopyramide
Drugs causing lung fibrosis
amiodarone
cytotoxic agents: bleomycin
anti-rheumatoid drugs: methotrexate, sulfasalazine
nitrofurantoin
ergot-derived dopamine receptor agonists (bromocriptine, cabergoline)
What drug class predisposes to cataracts
steroids
What drugs can cause corneal opacities?
amiodarone
indomethacin
What drugs can cause optic neuritis?
ethambutol
amiodarone
metronidazole
What drugs can cause retinopathy?
chloroquine
quinine
Sildenafil can cause which ocular side effects?
Blue discolouration of vision
Non-arteritic anterior ischaemic neuropathy
Drug induced photosensitivity
Thiazides
Antibiotics:
tetracyclines, sulphonamides, ciprofloxacin
amiodarone
NSAIDs e.g. piroxicam
sulphonylureas
Drugs which could precipitate an acute intermittent porphyria
barbiturates
halothane
benzodiazepines
alcohol
oral contraceptive pill
sulphonamides
Drug causes of agranulocytosis
Antithyroid drugs - carbimazole, propylthiouracil
Antipsychotics - atypical (CLOZAPINE)
Antiepileptics - carbamazepine
Antibiotics - penicillin, chloramphenicol, co-trimoxazole
Antidepressant - mirtazapine
Cytotoxic drugs - methotrexate
Drugs which commonly cause urticaria
aspirin
penicillins
NSAIDs
opiates
