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MRCP Pharmacology > Adrenoceptors > Flashcards

Adrenoceptors Flashcards

1
Q

Role of alpha-1 adrenoceptors

A

vasoconstriction
relaxation of GI smooth muscle
salivary secretion
hepatic glycogenolysis

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2
Q

Role of alpha-2 adrenoceptors

A

mainly presynaptic: inhibition of transmitter release (NA/Ach)
inhibits insulin
platelet aggregation

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3
Q

Role and location of beta-1 adrenoceptors

A

mainly located in the heart
increase heart rate + force

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4
Q

Role of beta-2 adrenoceptors

A

vasodilation
relax GI smooth mucsle
bronchodilation (2 LUNGS 1 HEART)

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5
Q

Role of beta-3 adrenoceptors

A

lipolysis

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6
Q

What type of receptor are all adrenoceptors?

A

G-protein coupled

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7
Q

What protein do alpha-1 adrenoceptors activate?

A

phospholipase C → IP3 → DAG
alpha-2: inhibit adenylate cyclase
beta-1: stimulate adenylate cyclase
beta-2: stimulate adenylate cyclase
beta-3: stimulate adenylate cyclase

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8
Q

What protein do alpha-1 adrenoceptors activate?

A

phospholipase C → IP3 → DAG

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9
Q

What protein do alpha-2 adrenoceptors inhibit?

A

adenylate cyclase

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10
Q

Beta-adrenoceptors stimulate what protein?

A

adenylate cyclase

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11
Q

Give an example of an alpha-1 AGONIST

A

phenylephrine

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12
Q

Give an example of an alpha-2 AGONIST

A

Clonidine

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13
Q

Give an example of a beta-1 AGONIST

A

Dobutamine

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14
Q

Give an example of a beta-2 AGONIST

A

Salbutamol

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15
Q

Give an example of an alpha-1 antagonist

A

1 Doxazosin
1a Tamsulosin

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16
Q

Give an example of an alpha-2 antagonist

A

Yohimbine

17
Q

Give an example of a beta-1 antagonist

A

Atenolol

18
Q

Give an example of a non-selective beta antagonist

A

Propranolol

19
Q

Give examples of mixed alpha and beta antagonists

A

Carvedilol
Labetalol

MRCP Pharmacology (22 decks)

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