Anaesthetic Agents Flashcards
1
Q
Mechanism of action of propofol
A
GABA receptor agonist
2
Q
Advantages of using propofol
A
- Rapid onset of anaesthesia
- Rapidly metabolised with little accumulation of metabolites
- Proven anti emetic properties
3
Q
Disadvantages of propofol
A
Pain on IV injection
Moderate myocardial depression
4
Q
Give some examples of the uses of propofol
A
- maintaining sedation on ITU
- Total IV anaesthesia (TIVA)
- Daycase surgery
5
Q
When is sodium thiopentone most commonly used and why?
A
Rapid Sequence Induction (RSI)
Extremely rapid onset of action
6
Q
Disadvantages of sodium thiopentone
A
- Marked myocardial depression
- Metabolites build up quickly
- Unsuitable for maintenance infusion
- Little analgesic effects
7
Q
Mechanism of action of ketamine
A
NMDA receptor antagonist
8
Q
Advantages of ketamine as anaesthetic agent
A
- can be used for induction
- moderate to strong analgesic properties
- mild myocardial depression => suitable for those who are haemodynamically unstable
9
Q
Advantages of Etomidate
A
- favorable cardiac safety profile
- very little haemodynamic instability
10
Q
Disadvantages of Etomidate
A
- No analgesic properties
- Unsuitable for maintaining sedation as prolonged use may result in adrenal suppression
- Post-op vomiting is common
