Oxazolidinones Exam 1 Drug List

Question 1

Oxazolidinones Drug Names

Answer 1

Linezolid (zyvox)

Question 2

Linezolid MOA

Answer 2

Inhibits bacterial ribosomal protein synthesis. Unique in that it stops the first step of synthesis by binding to the 50s subunit and preventing formation of the 70s complex

Question 3

Linezolid Susceptible Organisms

Answer 3

Aerobic, Gram-Positive

Retains activity against Enterococcus (VRE included)

group A/B StrepS. pneumoniae, E. faecalis, E. faecium, S. Aureus MRSA/SA

Question 4

Linezolid Absorption

Answer 4

Rapid/complete after oral admin

Question 5

Lenezolid Distribution

Answer 5

31% Protein Bound - Conc. Dependent
High concentration found in skin and well-perfused areas (exceeding plasma)

Question 6

Linezolid Metabolism

Answer 6

Nonenzymatic. Does not utilize CYP
Oxidation of morpholone ring creates 2 inactive metabolites of linezolid

Question 7

Linezolid Excretion

Answer 7

30% unchanged in urine
65% nonrenal excretion

Question 8

Linezolid Drug Interactions

Answer 8

MAOI/SSRI/Tricyclic Antidepressants/Ondansetron/Meperidine/Buspirone/Methadone/Tramadol
* Linezolid is reversible, nonselective inhibitor of monoamine oxidase
* Possible Serotonin syndrome

Question 9

Linezolid Precaution Pharmacotherapeutics

Answer 9

MAOI - Serotonin Syndrome or Hypertension
Reported to cause Myelosuppression
Preterm/Neonates - Reduce dose due to slower clearance

Question 10

Linezolid Indications

Answer 10

First Line VRE
Greater cure rates of MRSA than Vanco

Question 11

Linezolid Other Considerations

Answer 11

Reserve for moderate to severe infections when alternate antibiotics may not be effective, safe,cost effective, or resistance is present