Gentomycins Exam 1 Drug List

Question 1

Glycopeptides Drugs

Answer 1

Vancomycin

Question 2

Glycopeptide Susceptible Organisms

Answer 2

Gram Positive that are resistant to First-Line abx

Question 3

Vancomycin MOA

Answer 3

Inhibits cell wall synthesis by bindind to peptidoglycan systhesis enzymes

Question 4

Bacteriostatic/Cidal?

Vancomycin

Answer 4

Bactericidal

Question 5

Vancomycin Absorption

Answer 5

Poor PO absorption (1% F)

Question 6

Vancocycin Distribution

Answer 6

52-56% Protein bound
Widely distributed, 20-30% entering CSF
Crosses Placenta

Question 7

Vancomycin (PO) Metabolism

Answer 7

Minimal due to poor absorption

Question 8

Vancomycin Excretion

Answer 8

PO- Mainly Fecal
IV - Renal; 90% gomerular filtration

Question 9

Vancomycin Precautions

Answer 9

IV - Nephrotoxic, Vanc Infusion Syndrome (Severe Hypotension), Pregnancy Categopory C (AVOID)
PO - Preg Category B. Safe

Question 10

Vancomycin Drug Interactions

Answer 10

Zosyn - Severely nephrotoxic (3x higher)
Vanc Infusion Syndrome

Question 11

Vancomycin (PO) Indication

Answer 11

CDI