Chapter 9: Cannabis

Question 1

The Endocannabinoid system is composed of (3 things):

Answer 1

1. Cannabinoids
2. Cannabinoid receptors
3. Enzymes associated w/ synthesis and degradation

Question 2

What are the two types of cannabinoid receptors?

Answer 2

CB1 & CB2

Question 3

What type of protein receptors are Cannabinoid receptors?

Answer 3

G-Protein Coupled receptors

Question 4

What is the active compound in cannabis which has psychoactive properties?

Answer 4

THC

Question 5

What are the three types of cannabinoids that bind to cannabinoid receptors?

Answer 5

1. endogenous
2. derived from cannabis
3. synthetic

Question 6

CB1 receptors are located where?

Answer 6

Central Nervous System

Question 7

CB2 receptors are located where?

Answer 7

Immune cells & tissues, spinal column, bone marrow & the brain

Question 8

What is the primary therapeutic effect of CBD?

Answer 8

Pain relief

Question 9

Nabiximols (Sativex) is used to treat pain for which condition?

Answer 9

Multiple sclerosis

Question 10

What is Dronabinol (Marinol) is used to treat?

Answer 10

Nausea and vomiting r/t chemotherapy and AIDS

Question 11

What drug schedule is Dronabinol (Marinol)?

Answer 11

Schedule 3

Question 12

Which cannabinoid receptor is responsible for the psychoactive effects?

Answer 12

CB1

Question 13

Which cannabinoid receptor is responsible for the pain relief properties seen in chronic pain and neurodegenerative disease?

Answer 13

CB2

Question 14

True or False:
Both THC and CBD are hydrophilic and are metabolized by the kidneys

Answer 14

False: they are highly lipophilic and metabolized by the liver

Question 15

What schedule is Nabilone (Cesamet) & what is it used for?

Answer 15

Schedule II
Nausea & Vomit from chemotherapy

Question 16

Name a CBD only product used for treatment of seizures:

Answer 16

Epidiolox

Question 17

When inhaled, cannabis reaches peak blood levels in ____ minutes & has a duration of ___to___hours:

Answer 17

30 minutes
1-3.5 hours

Question 18

When ingested, cannabis has an onset of:
___ minutes to __hours

Answer 18

30 minutes to 2 hours

Question 19

When ingested, cannabis has a duration of:

Answer 19

5-8 hours

Question 20

When ingested cannabis is metabolized by?

Answer 20

The liver via first pass

Question 21

Evidence has supported the use of cannabinoids to treat these conditions:

Answer 21

1: chronic pain
2. chemotherapy induced nausea and vomiting
3. pediatric epilepsy/seizures
4. pain/spasticity in multiple sclerosis
5. Glaucoma

Question 22

Cannabinoids can be used to treat these conditions even though evidence has been inconclusive:

Answer 22

1. anxiety/depression
2. Tourette
3. PTSD
4. Anorexia

Question 23

Adverse Effects of cannabinoids:

Answer 23

1. xerostomia
2. Somnolence/drowsiness
3. Vertigo/Dizziness
4. Ataxia

Question 24

What is the relation between maternal cannabis use & newborns?

Answer 24

Lower birth weight newborns in maternal use

Question 25

Chronic smokers can develop this condition

Answer 25

Cannabinoid hyperemesis syndrome

Question 26

What effects could cannabis have on patients who suffer from a mental health diagnosis?

Answer 26

1. can increase risk of schizophrenia and/or other psychosis
2. Bipolar patients have more bipolar symptoms
3. Can have more suicidal thoughts