Chapter 9: Cannabis Flashcards
The Endocannabinoid system is composed of (3 things):
- Cannabinoids
- Cannabinoid receptors
- Enzymes associated w/ synthesis and degradation
What are the two types of cannabinoid receptors?
CB1 & CB2
What type of protein receptors are Cannabinoid receptors?
G-Protein Coupled receptors
What is the active compound in cannabis which has psychoactive properties?
THC
What are the three types of cannabinoids that bind to cannabinoid receptors?
- endogenous
- derived from cannabis
- synthetic
CB1 receptors are located where?
Central Nervous System
CB2 receptors are located where?
Immune cells & tissues, spinal column, bone marrow & the brain
What is the primary therapeutic effect of CBD?
Pain relief
Nabiximols (Sativex) is used to treat pain for which condition?
Multiple sclerosis
What is Dronabinol (Marinol) is used to treat?
Nausea and vomiting r/t chemotherapy and AIDS
What drug schedule is Dronabinol (Marinol)?
Schedule 3
Which cannabinoid receptor is responsible for the psychoactive effects?
CB1
Which cannabinoid receptor is responsible for the pain relief properties seen in chronic pain and neurodegenerative disease?
CB2
True or False:
Both THC and CBD are hydrophilic and are metabolized by the kidneys
False: they are highly lipophilic and metabolized by the liver
What schedule is Nabilone (Cesamet) & what is it used for?
Schedule II
Nausea & Vomit from chemotherapy
Name a CBD only product used for treatment of seizures:
Epidiolox
When inhaled, cannabis reaches peak blood levels in ____ minutes & has a duration of ___to___hours:
30 minutes
1-3.5 hours
When ingested, cannabis has an onset of:
___ minutes to __hours
30 minutes to 2 hours
When ingested, cannabis has a duration of:
5-8 hours
When ingested cannabis is metabolized by?
The liver via first pass
Evidence has supported the use of cannabinoids to treat these conditions:
1: chronic pain
2. chemotherapy induced nausea and vomiting
3. pediatric epilepsy/seizures
4. pain/spasticity in multiple sclerosis
5. Glaucoma
Cannabinoids can be used to treat these conditions even though evidence has been inconclusive:
- anxiety/depression
- Tourette
- PTSD
- Anorexia
Adverse Effects of cannabinoids:
- xerostomia
- Somnolence/drowsiness
- Vertigo/Dizziness
- Ataxia
What is the relation between maternal cannabis use & newborns?
Lower birth weight newborns in maternal use
Chronic smokers can develop this condition
Cannabinoid hyperemesis syndrome
What effects could cannabis have on patients who suffer from a mental health diagnosis?
- can increase risk of schizophrenia and/or other psychosis
- Bipolar patients have more bipolar symptoms
- Can have more suicidal thoughts
