Overview of Autonomic Pharmacology Flashcards
Which of the sub units in nicotinic receptors are for somatic and for ANS
Alpha 1 = Somatic
Alpha 2 -7 = ANS
What is Hexamethonium
Non-competitive, selective antagonist for neuronal sub type of nicotinic receptors
Block all autonomic
What type of receptros are in parasympathetic post ganglions
Muscarinic Receptors
Give examples of Parasymphatomimetics
Muscarinic agonist
ACh, Muscarine, Pilocarpine
Patient presents with bradycardia, colicky pain (increased gut motility), Bronchoconstriction, pupillary constriction, airway secretion
Muscarine poisoning
What is used to treat glaucoma
Pilocarpine
How does Pilocarpine treat glaucoma
Injected into top of eye
Improve aqueous humour drainage
Drop in intra-occular pressure
No systemic effect
Why are less specific muscarine antagonist used instead of specific
Hard to get specific antagonist into body
What are some of the clinical uses of antimuscarinic drugs
Asthma: Lipratropium block para nerves which narrows airway
Atropine treats bradycardia
Pirenzapine reduces gut motility
What are the uses of alpha agonists
Vasoconstrictors with LA
Nasal decongestants
Hypertension
What are the uses of alpha antagonist
Hypertension
Benign Prostatic Hyperplasia
What are the uses of beta agonist
Cardiogenic shock if BP too low
Anaphylactic shock
Asthma
Eg. Adrenaline
What are the uses of Beta antagonist
Angina Cardiac Arrhythmia Anxiety Chronic Heart Failure Glaucoma (locally)
Eg. Metoprolol
How are catecholamines uptaken
Neuronal due to primary active transporter norepineprhrine transporter
Co-transports Na+, Cl- and Catecholamines
What inhibits catecholamine uptake
NET Inhibtors
Desipramine
Cocaine
