Damage and Repair in the Injured CNS Flashcards
What do white matter tracts provide
Communication between SC and brain
What does a CNS nerve injury cause
Loss of sensory, motor and autonomic function below level of injury
What are the most common CNS injuries
Traumatic Brain injury
Spinal Cord injury
What is the injury response
Lesion cavity expands
Astrocytes seal of BBB to retain tissue integrity and restrain inflammatory response
Due to inhibitory molecules, there is deposition of ECM and glial scarring = barrier to regeneration
How do we know that CNS neurones have intrinsic capacity to regenerate
CNS axons placed in peripheral NS environment will regenerate
What are the inhibitory molecules associated with glial scarring
CSPG
What are the inhibitory molecules associated with damaged myelin
Nogo, MAP, DmgP
What is the therapeutic goal of repair
Improve repair
Improve quality of life
Enhance functional consequences
What are trophic factors
Growth factors that modulate neuronal survival and neurite growth
Give examples of molecules that inhibit inhibitory molecules
Anti-Nogo
Chondroitinase
Where do neural stem cells exist in CNS
Subventricular Zone = lateral walls of lateral ventricles
Subgranular Zone = dentate gyrus of hippocampus
What occurs in cell therapy
Replace dead cells
Create favourable environment
Bridge cyst/cavities with cell transplant
What are the advantages of Dental Pulp Stem Cells
Dont need immunosuppressants
