other routes admin

Question 1

buccal and sublingual
drug

Answer 1

tongue and oral cavity highly vascular
saliva facilitates dissolution
local or systemic
usually for drugs
- destroyed by low ph in stomach
decomposed in git
extensively metabolised by first pass metabolism
very onset, sublingual short, buccal longer

Question 2

buccal advantage

Answer 2

relatively quick onset
can be used for unconscious people
avoid first pass

Question 3

buccal disadvantage no

Answer 3

can’t swallow
bitter
must retain in mouth
more involved

Question 4

buccal advice

Answer 4

place in correct area
moisten mouth before hand
don’t eat it drink while taking
don’t swallow

Question 5

rectal

Answer 5

local or systemic
three veins - upper rectal vein to portal vein
middle and inferior avoid liver directly to system
slower absorption than oral
suppositories or enemas

Question 6

rectal advantage

Answer 6

used if oral unsuitable
- vomitting unconscious young
useful for gi irritants
useful for drugs destroyed by stomach or s i
useful local effects
avoid 50% first pass

Question 7

rectal disadvantage

Answer 7

unpredictable absorption
not as convenient
low patient acceptability

Question 8

rectal advice

Answer 8

poop wash hands
remove all wrapper
lube it - water
disposable gloves
don’t poop 1 hour