Other Bacteria Flashcards
Undulating fever
Brucella abortus
Infection from rabbits, deer or rodents; transmitted by tick bite (dermacentor)
Tularemia (Francisella tularensis)
Most virulent bacteria; causes buboes and cutaneous hemorrhage
Yersinia pestis (plague)
Animal bite infection
Pasturella multocida
Buttery colonies of pasturella multocida with musty odor due to production of _________
Indole
Reproductive tract infection in cattle, infection through contaminated dairy or direct contact with cows
Brucella abortus
Uses heat to stabilize carbolfuscin
Ziehl-Neelsen
Uses detergent to stabilize carbolfuscin
Kinyoun
Lipids of mycobacterium tuberculosis (2)
- Mycolic acid, 2. Wax D
Prevents phagolysosome fusion in M. tuberculosis
Exported repetitive protein (sulfatides)
Prevents leukocyte migration in TB
Cord factor
Delayed hypersensitivity against TB; basis for the PPD test
Tuberculin surface protein
Subpleural TB granuloma
Ghon’s focus
Ghon’s focus + lymph node
Ghon’s complex
Radiologically detectable TB calcification
Ranke’s complex
Reactivation TB, usually in the apices
Simon’s focus
TB may be secondarily infected with ____________
Aspergillus fumigatus
PPD cutoff value: Philippines
> 8mm
PPD cutoff value: immunosuppressed
> 5mm
PPD cutoff value: high risk population
> 10 mm
PPD cutoff value: low risk population
> 15 mm
Most common extrapulmonary TB
Scrofula
Other use of BCG vaccine other than TB prevention
Intravesical injection for urinary bladder CA
Pulmonary disease when CD4
Mycobacterium avium intracellulare complex
Must be cultured on the footpads of a mouse or armadillo
Mycobacterium leprae
Macrophages filled with M. leprae
Globi
Free bacilli, not contained in globi
Red Snappers
Marked tissue destruction, many lesions, many acid-fast bacilli, high infectivity, negative lepromin skin test due to reduced or absent cell mediated response
Lepromatous leprosy
Minimal tissue destruction, few lesions, few acid-fast bacilli, low infectivity, positive lepromin skin test due to intact cell mediated response
Tuberculoid leprosy
Hypopigmented plaques, thickened superficial nerves and significant anesthesia
Tuberculoid leprosy
Leonine facies, erythema nodosum leprosum
Lepromatous leprosy
- Tx for lepromatous leprosy
2. Side effects of the drugs
- Dapsone (methemoglobinemia), 2. Rifampicin (hepatotoxic, orange colored secretions), 3. Clofazimine (bronze discoloration)
- Tx for erythema nodosum leprosum
2. Side effect of the drug
- Thalidomide
2. Phocomelia
Hard, nontender swelling with sinus tracts draining sulfur granules
Actinomyces Israelii
Aerobic, filamentous gram positive rods with aerial hyphae, weakly acid fast on Fite-Faraco stain
Nocardia asteroides
Mycetomas, orange colonies of lung and brain abscesses
Nocardia asteroides
Only bacteria with sterol in its cell membrane; produces P1 adhesin, H2O2, cold agglutinins
Mycoplasma pneumoniae
“Walking pneumonia”; associated with SJS (most common cause), Raynaud’s phenomenon, Guillain-Barre syndrome
Mycoplasma pneumoniae
Coiled microaerophilic spirochete; seen on darkfield microscopy
Treponema pallidum
Nontender chancre
Primary syphilis
Condyloma lata, maculopapular rash
Secondary syphilis
Gummas, Neurosyphilis, tree-bark aortitis
Tertiary syphilis
Pupils that are unreactive to light but are able to accommodate
Argyll-Robertson pupil (prostitute’s pupil)
Snuffles, mulberry molars, saber shins, pulmonary hemorrhage, Clutton’s joints (synovitis)
Congenital syphilis
Hutchinson triad in congenital syphilis
Hutchinson teeth, deafness, keratitis
Unilateral enlargement of the sternoclavicular portion of the clavicle, leading to detachment
Higoumenakis sign
Screening test for syphilis
RPR/VDRL
Confirmatory test for syphilis
FTA-ABS
Influenza-like symptoms occurring a few hours after commencing treatment with Penicillin G
Jarisch-Herxheimer reaction
Diseases transmitted by the deer tick (Ixodes scapularis) (2)
- Babesia microti, 2. Borrelia burgdorferi
Erythema chronicum migrans (target lesions)
Stage 1 of Lyme disease
Myocarditis, meningitis, Bell’s palsy
Stage 2 of Lyme disease
Autoimmune migratory polyarthritis, onion-skin lesions, acrodermatitis chronica atrophicans
Stage 3 of Lyme disease
Causes Relapsing Fever due to programmed rearrangements; transmitted by Pediculus humanus
Borrelia recurrentis
Thin, coiled spirochetes with “Shepherd’s crook” appearance
Leptospira interrogans
Gold standard in the diagnosis of leptospirosis
LeptoMAT (microscopic agglutination test)
Febrile illness, with intense calf tenderness, conjunctival suffusion
Acute leptospiremic phase
Aseptic meningitis, snowflake pulmonary lesions on CXR, hepatic necrosis, Type 3 hypersensitivity mediated glomerulonephritis
Immune leptospiruric phase
Triad of jaundice, bleeding, uremia; with orange cast skin and massive pulmonary hemorrhage
Weil syndrome
Obligate intracellular bacteria (2)
- Chlamydia, 2. Rickettsia
Inactive, extracellular chlamydia; infectious form that enters the cell thru endocytosis
Elementary body
Metabolically active, intracellular chlamydia; comprises the cytoplasmic inclusions seen on Giemsa stain
Reticulate body
Most common STD overall
Chlamydia trachomatis
Chronic keratoconjunctivitis, Halberstadter-Prowazek inclusions near the nuclei of conjunctival epithelial cells
Trachoma (types A-C)
Non-gonorrheal urethritis in males, PID in females; neonatal conjunctivitis and pneumonia; associated with Reiter’s syndrome
Chlamydia types D-K
Late onset; tachypnea, staccato cough, absence of fever, eosinophilia
Chlamydia neonatal pneumonia
Inguinal lymphadenitis (buboes), (+) Groove sign
Lymphogranuloma venereum (types L1-L3)
Atypical pneumonia associated with atherosclerosis
Chlamydia pneumoniae
Sudden onset pneumonia with a history of exposure to exotic birds
Chlamydia psittaci (Bird fancier’s disease)
Cross reaction of rickettsiae with antigens of OX strains of proteus vulgaris
Weil-Felix reaction
Rocky mountain spotted fever
Rickettsia rickettsii
Rickettsial infection with eschar formation
Rickettsia akari
Epidemic rickettsia
Rickettsia prowazekii
Endemic rickettsia
Rickettsia typhi
Scrub typhus
Orientsia tsutsugamushi
Q fever; no vector, no rash, high mortality rate
Coxiella burnetti
Cat scratch disease in immunocompetent; bacillary angiomatosis in immunocompromised
Bartonella henselae
Transmitted by dog tick bite (Dermacentor); forms morulae in the cytoplasm of monocytes
Ehrlichia chaffensis
Clue cells, positive whiff test; fishy, malodorous vaginal discharge
Gardnerella vaginalis
Painful genital ulcer; cultured on chocolate agar with Factor X
Haemophilus ducreyi (chancroid)
Mesenteric adenitis
Yersinia enterocolitica
Donovan bodies, beefy red genital ulcers with pseudobuboe formation
Klebsiella granulomatis (granuloma inguinale/donovanosis)