OSTEOSCLEROTIC CONDITIONS

Question 1

What is Osteopetrosis ?

Answer 1

A disease were there is a deficiency of osteoclast function that causes dense bone.

Question 2

What are the risks of Osteopetrosis ?

Answer 2

The bone is brittle so is prone to fracturing. (Although looks dense)

Question 3

What are 4 classic Xray appearance of Osteopetrosis ?

Answer 3

1. Bone within bone appearances.
2. Tubular bones may have flask like deformity.
3. Lack of differentiation between cortical bone and medullary bone.

Question 4

What is Osteopetrosis also known as ?

Answer 4

Albers schonberg disease or marble bone disease.

Question 5

Give a list of differentials for OSTEOSCLEROTIC appearance of bone?

Key (There’s a pneumonic)

Answer 5

Renal osteodystrophy.
Sickle cell disease
Myelofibrosis
Osteopetrosis
Pyknodysostosis
Metastatic carcinoma
Pagets
Athletes
Fluorosis.

Question 6

How does renal osteodystrophy present on hand plain films?

Answer 6

Subperiosteal bone reabsorption seen mostly at the radial aspect of the middle phalanx’s. Some patients will be osteopenic.

Question 7

Osteosclerosis in sickle cell disease has an unknown cause, what is the radiographic appearance in the spine?

Answer 7

Step off or H shaped deformities of the vertebral body endplates.

Question 8

What blood marker can be used to see if a patient has osteoblastic Mets ?

Answer 8

The enzyme called Alkaline Phosphatase.