Osteoarthritis Flashcards
where are nerve endings in joint?
in the fibrous capsule
Is there fibrin normally in joint fluid?
no - does not clot
when is there fibrin in the joint fluid?
inflammation
what is this?
synovial effusion - Bog Spavin
which layer of articular hyaline cartilage is stressed in tension?
tangential layer
what does healing of articular hyaline cartilage involve?
removal of calcified cartilage
what is the ground substance of a joint compromised of?
What sustains cyclic deformation in articular hyaline cartilage?
radial layer
How is the ground substance oriented?
vertically
what is responsible for tensile strength and compressive stiffness in articular hyaline cartilage?
tensile strength - tangential zone
compressive stiffness - radial zone
which is boundary lubrication and hydrostatic lubrication?
boundary lubrication - A
hydrostatic lubrication - B
what is subchondral bone?
what is the inciting cause of degenerative joint disease?
direct injury, biochemical degradation (inflammation > sepsis, iatrogenic (steroid))
what is the end result of degenerative joint disease?
osteoarthritis
How does the joint space appear in radiographs for osteoarthritis?
joint space narrowing on radiographs
which is normal which is diseased? what is it?
what is seen is this image? what disease is this?
what are examples of abnormal stresses on normal cartilage leading to DJD?
chondral/osteochondral injury, joint instability, steroid (MPA) injections
what are normal stresses on abnormal cartilage that leads to DJD?
synovitis, capsulitis, osteochondrosis
what is the glue that hold collagen together?
GAG (ground substance)
which is normal and which is not? what could have caused the pathology?
normal left, right GAG loss
steroid induced GAG loss - methylprednisolone acetate/Depomedrol
what is the most potent degenerator of articular cartilage?
depomedrol
what is seen here?
cartilage fibrillation - collagen lost ground substance
what is seen here?
collagen fibers that have lost ground substance
