orientation to pharmacology Flashcards

1
Q

pharmacodynamics

A

the drug’s effects on the body

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

pharmacology

A

study of drugs and their interactions with living systems

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

pharmacokinetics

A

study of what the body does to the drug

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

pharmacotherapeutics

A

study of the medical use of drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what should the nurse prioritize when administering a drug

A

intensity of the response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

three most important characteristics a drug has

A
  • safety
  • selectivity
  • effectiveness (THE MOST MOST IMPORTANT)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

objective of drug therapy

A

to provide maximum benefit with minimal harm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

characteristics that determine the patient’s response to a drug

A

age, weight, sex, genetics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

prototype drug

A

a great representation of all drugs in that classification; usually the first drug in its class

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

orphan drug

A

abandoned drug; way too much money to make OR not worth to keep funding due to rarity of disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

off-label prescribing

A

drug found to work better for a different reason, but need to go back to Phase I for testing that reason, → taking off label for another reason

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

legend drugs

A

drug that you need prescription for

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

complementary and alternative medicine (CAM)

A

treatment practice that are not widely accepted to practiced by mainstream clinicians in a given culture (herbal supplements)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

black box warning

A

highlights the most serious warning

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

chemical name

A

describes chemical makeup of the drug, assigned to every drug

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

generic name

A

based on chemical makeup with a prefix and suffix, DO NOT CAPITALIZE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

trade name

A

manufacturer name given by a company that sells it, CAPITALIZE THIS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what are big differences between generic vs trade name drugs

A
  1. cost
  2. bioavailability
  3. pharmacist may need approval from health care provider before substituting generic
19
Q

bioavailability

A

rate + extent to which the active ingredients are absorbed and made available at the site of action

(there can be enough of a difference with bioavailability in generic and trade)

20
Q

chemical composition

A

describes chemical base of the drug

21
Q

physiologic effect

A

which body system the drug is affecting

22
Q

therapeutic use

A

pt response after treatment

23
Q

what are the phases of clinical development

A
  1. preclinical testing
  2. clinical trials
    - phase 1
    - phase 2
    - phase 3
    - FDA reporting
    - phase 4
24
Q

preclinical testing

A
  • testing done on anything alive except humans (usually rats)
25
phase 1 clinical trial
- healthy humans (college students) - chemical name - purpose: find pharmacokinetics, biologic effects, metabolism of the drug
26
phase 2 clinical trials
- will this drug actually treat _____ - what is the possible dose range - chemical name - purpose: find adverse effects and dosage range associated with the drug
27
phase 3 clinical trial
- bigger sample size - more side effects - chemical name - purpose: find risks associated with the drug, SAFETY and EFFECTIVENESS?
28
t/f: clinical trials are always double blind studies
true
29
fda reporting of clinical trial
- where drug gets generic name
30
phase 4 of clinical trial
- cont. forever (can be taken off the market anytime) - purpose: find efficiency of the drug with respect to other drugs in the market belonging to the same therapeutic category
31
pure food and drug act of 1906
- first law to regulate drugs - power to gov to take over sanitary conditions
32
sherley amendment of 1912
businesses cannot claim results from drugs until they can prove it
33
federal food, drug, and cosmetic act of 1938
first legislation to address drug safety
34
harris-kefauver amendment
- tighter control of drugs in the US - drug efficacy had to be PROVEN and SAFE before US market
35
harrison narcotic act
- regulated + taxed prod/import/distribution of opiates and coca products
36
controlled substances act of the 1970s
- "schedule" categories for all narcotic drugs to regulate use
37
prescription drug user fee act of 1992
- if big pharm pays gov money, drugs can be released faster and skip clinical trials - usually used in emergency
38
food and drug administration modernization act of 1997
- companies need to give 6 month notice before they stop the marketing of a drug
39
fda amendments act of 2007
- fda has more control over drugs
40
schedule I drug --> examples?
drugs with no medical use, not being testing bc NO medical reason to ex: cocaine, meth, heroin, marijuanna
41
schedule ii
- drugs with medical reasons BUT with the most restriction due to addictiveness and toxicity, abuse potential - typically no refills
42
schedule iii drug
- used for medical reasons - less restrictions and less addictive - refills available
43
schedule iv drug
- used for medical reasons - OTC but just ask pharmacist