immunity pt 2 - meds that inhib protein synthesis Flashcards
tetracycline
C:
MOA:
SOA:
CI:
C: antibiotic; tetracycline
MOA: inhib protein synthesis, bacteriostatic
SOA: +,-; anaerobes, broad spectrum
CI: tetracycline allergies, preg category D, children <8yrs
tetracycline
K: where accumulate?
INT:
K: accumulates in bone, liver, sal glands
INT: antacids, calcium, BC, PCN G, warfarin
SE of tetracycline
tooth discoloration, dec BC effect, superinfection, photosensitivity
pt education with tetracycline
no children, no dairy
antacids and mineral salts 2-3 hrs after
wear sunscreen
take other forms of BC
gentamicin
C:
MOA:
SOA:
CI:
C: antibiotic; aminoglycoside
MOA: bind to ribosome, inhib protein synthesis, bactericidal
SOA: - anaerobes
CI: dehydration, myasthenia gravis, previous hearing loss, preg, allergy
gentamicin
K: max days, how to give dose?
INT:
K: no longer than >10 days, single large dose or 2-3 small dose
INT: DO NOT GIVE WITH OTHER MEDS AT SAME TIME
SE of gentamicin
renal, oto, hepatotoxicity
BBW of gentamicin
neuromuscular block
pt education with gentamicin
- __ before a meal or ___ after a meal
take on empty stomach, inc fluid intake
1hr before, 2hrs after a meal
what are other aminoglycosides?
amikacin, neomycin, tobramycin
clindamycin
C:
MOA:
SOA:
CI:
C: antibiotic; lincosamides
MOA: inhib protein synthesis by binding to ribosome; bacteriostatic/cidal
SOA: + aerobes, - anaerobes
CI: hx of asthma (b.spasms), allergy, preg
clindamycin
K: IM O= IV O =
SE:
K: IM O = 20-30min, IV O = minutes, high PB, watch LFT
SE: dec contraceptive effect, dry skin, rash, GI upset
BBW of clindamycin
c.diff, diarrhea
pt education with clindamycin
take other forms of BC
what is another lincosamide antibiotic?
lincomycin
erythromycin
C:
MOA:
SOA:
I:
C: antibiotic; macrolide
MOA: bind to ribosome, inhib protein synthesis; bacteriostatic/cidal
SOA: +,- wide spectrum, anaerobes
I: for pts allergic to PCN, resp infection
erythromycin
K:
SE:
K: high PB
SE: initial diarrhea (c.diff?), pain on hanging, OT prolongation, nephrotoxicity, sudden cardiac death
how can a nurse reduce the pain upon hanging a bag of erythromycin
- what to do if pain mgmt fails
- slow infusion
- ice pack and cold compress
fail to reduce pain = call MD and order lidocaine
pt education with erythromycin
take on empty stomach, eat bland food if GI upset
what are other macrolide antibiotics
azithromycin, clarithromycin
ciprofloxacin (Cipro)
C:
MOA:
SOA:
I:
CI:
C: antibiotic; fluoroquinoles
MOA: inhib DNA supercoiling
SOA: +,- anaerobes
I: children >13,14 yrs
CI: children <13yrs
ciprofloxacin (Cipro)
INT:
SE:
INT: turn off tube feedings, antacids, caffeine, dairy, warfarin, procainimide
SE: peripheral neuropathy, phototoxicity, GI upset, rash
BBW of ciprofloxacin
joint disease, tendon rupture, myasthenia gravis flare up
what are other fluoroquinolone antibiotics
levofloxacin, moxifloxacin
