immunity pt 2 - meds that inhib protein synthesis

Question 1

tetracycline
C:
MOA:
SOA:
CI:

Answer 1

C: antibiotic; tetracycline
MOA: inhib protein synthesis, bacteriostatic
SOA: +,-; anaerobes, broad spectrum
CI: tetracycline allergies, preg category D, children <8yrs

Question 2

tetracycline
K: where accumulate?
INT:

Answer 2

K: accumulates in bone, liver, sal glands
INT: antacids, calcium, BC, PCN G, warfarin

Question 3

SE of tetracycline

Answer 3

tooth discoloration, dec BC effect, superinfection, photosensitivity

Question 4

pt education with tetracycline

Answer 4

no children, no dairy
antacids and mineral salts 2-3 hrs after
wear sunscreen
take other forms of BC

Question 5

gentamicin
C:
MOA:
SOA:
CI:

Answer 5

C: antibiotic; aminoglycoside
MOA: bind to ribosome, inhib protein synthesis, bactericidal
SOA: - anaerobes
CI: dehydration, myasthenia gravis, previous hearing loss, preg, allergy

Question 6

gentamicin
K: max days, how to give dose?
INT:

Answer 6

K: no longer than >10 days, single large dose or 2-3 small dose
INT: DO NOT GIVE WITH OTHER MEDS AT SAME TIME

Question 7

SE of gentamicin

Answer 7

renal, oto, hepatotoxicity

Question 8

BBW of gentamicin

Answer 8

neuromuscular block

Question 9

pt education with gentamicin
- __ before a meal or ___ after a meal

Answer 9

take on empty stomach, inc fluid intake
1hr before, 2hrs after a meal

Question 10

what are other aminoglycosides?

Answer 10

amikacin, neomycin, tobramycin

Question 11

clindamycin
C:
MOA:
SOA:
CI:

Answer 11

C: antibiotic; lincosamides
MOA: inhib protein synthesis by binding to ribosome; bacteriostatic/cidal
SOA: + aerobes, - anaerobes
CI: hx of asthma (b.spasms), allergy, preg

Question 12

clindamycin
K: IM O= IV O =
SE:

Answer 12

K: IM O = 20-30min, IV O = minutes, high PB, watch LFT
SE: dec contraceptive effect, dry skin, rash, GI upset

Question 13

BBW of clindamycin

Answer 13

c.diff, diarrhea

Question 14

pt education with clindamycin

Answer 14

take other forms of BC

Question 15

what is another lincosamide antibiotic?

Answer 15

lincomycin

Question 16

erythromycin
C:
MOA:
SOA:
I:

Answer 16

C: antibiotic; macrolide
MOA: bind to ribosome, inhib protein synthesis; bacteriostatic/cidal
SOA: +,- wide spectrum, anaerobes
I: for pts allergic to PCN, resp infection

Question 17

erythromycin
K:
SE:

Answer 17

K: high PB
SE: initial diarrhea (c.diff?), pain on hanging, OT prolongation, nephrotoxicity, sudden cardiac death

Question 18

how can a nurse reduce the pain upon hanging a bag of erythromycin
- what to do if pain mgmt fails

Answer 18

• slow infusion
• ice pack and cold compress
  fail to reduce pain = call MD and order lidocaine

Question 19

pt education with erythromycin

Answer 19

take on empty stomach, eat bland food if GI upset

Question 20

what are other macrolide antibiotics

Answer 20

azithromycin, clarithromycin

Question 21

ciprofloxacin (Cipro)
C:
MOA:
SOA:
I:
CI:

Answer 21

C: antibiotic; fluoroquinoles
MOA: inhib DNA supercoiling
SOA: +,- anaerobes
I: children >13,14 yrs
CI: children <13yrs

Question 22

ciprofloxacin (Cipro)
INT:
SE:

Answer 22

INT: turn off tube feedings, antacids, caffeine, dairy, warfarin, procainimide
SE: peripheral neuropathy, phototoxicity, GI upset, rash

Question 23

BBW of ciprofloxacin

Answer 23

joint disease, tendon rupture, myasthenia gravis flare up

Question 24

what are other fluoroquinolone antibiotics

Answer 24

levofloxacin, moxifloxacin

Question 25

drugs to take if pt has PCN allergy

Answer 25

aztreonem, erythromycin

Question 26

drugs with BBWs

Answer 26

gentamicin: neuromuscular block
clindamycin: c.diff, diarrhea
ciprofloxacin: joint disease, tendon rupture, myasthenia gravis flare up

Question 27

drugs to take on empty stomach

Answer 27

tetracycline, erythromycin, gentamicin, ciprofloxacin

Question 28

bactericidal drugs

Answer 28

vancomycin, gentamicin, PCN, cephalosporin

Question 29

bacteriostatic drugs

Answer 29

tetracycline, trimethoprim

Question 30

bacteriostatic/cidal drugs

Answer 30

clindamycin, erythromycin