ans patho

Question 1

jobs of ANS (reg 3 things?)

Answer 1

reg smooth muscle, heart, secretory glands

Question 2

ANS Ts that trigger SNS response

Answer 2

Ach, NE, EPI

Question 3

enzymes that destroy Ach

Answer 3

acetylcholinesterase, pseudocholinesterase

Question 4

enzymes that destroy NE

Answer 4

MAO, COMT (NE in bloodstream)

Question 5

enzymes that destroy EPI

Answer 5

hepatic metabolism (P-450)

Question 6

where is the only place with arterial dilation

Answer 6

coronary artery dilation when SNS effects occur

Question 7

structure of SNS fibers

Answer 7

short preganglionic, long post ganglionic that innervates many organs

Question 8

structure of PNS fibers

Answer 8

long preganglionic

Question 9

receptors for SNS

Answer 9

adrenergic receptors = alpha, beta

Question 10

receptors for PNS

Answer 10

cholinergic receptors = muscarinic, nicotinic

Question 11

alpha 1 receptor
- location
- response
- effects

Answer 11

location: smooth muscles, postsynapse
response: epi, ach, ne
effects: vasoconstrict, pupil dilate, ejaculation, bladder contraction

Question 12

alpha 2 receptor
- location
- response
- effects

Answer 12

location: presynapse
response: checks n balances for alpha 1 SNS
effects: inhibits release of NE, turns off SNS

Question 13

beta 1 receptor
- location
- response
- effects

Answer 13

location: heart
response/effects: increase rate + force of contraction, AV conduction

Question 14

beta 2 receptors
- location
- response
- effects

Answer 14

location: lungs
response/effects: bronchodilation, slow down preterm labor, glycogenolysis

Question 15

nicotinic N receptors
- location

Answer 15

location: nervous system, ans neurons, adrenal medulla

Question 16

nicotinic m receptor
- location
- response/effects

Answer 16

location: neuromuscular jxn
response/effects: contract skel muscle

Question 17

muscarinic receptor
- location
- response/effects

Answer 17

location: PNS, glands
response/effect: increase sweat, saliva

Question 18

what is a cholinergic crisis

Answer 18

muscarinic poisoning by direct acting muscarinic OR cholinesterase inhibitor

Question 19

s/s of cholinergic crisis

Answer 19

• profuse salivation, lacrimation
• visual disturbance
• bradycardia, hypotension, SOB
• abdominal cramps, n/v/d

Question 20

antidote for cholinergic crisis

Answer 20

atropine = anticholinergic

Question 21

effects of cholinergic drugs (SLUDGE?)

Answer 21

s - salivate
l - lacrimate
u - urinate
d - defecate
g - gi motility and tone
e - emesis

Question 22

effects of anticholinergics

Answer 22

can’t see, can’t spit, can’t pee, can’t shit