Organophosphates

Question 1

Etiology of poisoning - Organophosphate

Answer 1

• Organophosphates are used as Insecticides

Question 2

Mechanism of Action - Organophosphate

Answer 2

• Inhibition of Acethylcholinesterase Enzyme (AChE)
  -They are similar to Cholinesterase molecules and bind to the Enzymes active site
  -Resulting in Overbundance of Acethylcholine at the Neuroreceptor
  -Initially Stimulates and then Paralyze in Cholinergic Synapses and Nerve endings
  -Resulting in Stimulation of the Autonomic Nervous System, Skeletal Muscles and CNS

!If they contain Sulphur = can become more Toxic by Biotransformation!

Question 3

Clinical Symptoms - Organophosphate

Answer 3

• Salivation
• Diarrhoea
• Vomiting
• Cramps
• Seizures

Question 4

Treatment - Organophosphate

Answer 4

• Atropin

Question 5

Chemical-Toxicological Analysis (CHTA) - Organophosphate

Answer 5

• TLC - Thin layer chromatography
• GC - Gas chromatography