Alfatoxins

Question 1

Etiology of Poisoning - Alfatoxins

Answer 1

• Toxin produced by Aspergillus Flavus and Aspergillus Parasiticus
  -Aspergillus is a Genus of Mold found on Peanuts, Soybeans, Corn, Cereals
  -Found either in Field or Storage (High moisture and temperature)

Question 2

Mechanism of Action - Alfatoxins

Answer 2

• Toxic response and diesease in Mammals and Poultry varies in relation to:
  -Species
  -Sex
  -Age
  -Nutritional status
  -Duration of ingestion
  -Level of Alfatoxins
• Liver is the Principal Organ affected:
  -High doses = Hepatocellular Necrosis
  -Prolonged Low dose = Decreased Growth rate and Live Enlargment

Question 3

Clinical Symptoms - Alfatoxins

Answer 3

• Loss of Appetite, Vomiting
• Jaundice (Yellor colouring)
• Bruising, Bleeding
• Diarrhoea

Question 4

Treatment - Alfatoxins

Answer 4

• Symptomatic
• Supportive

Question 5

Chemical-Toxicological Analysis (CHTA) - Alfatoxins

Answer 5

• Chromatography
  -Results: Under UV B₁, B₂=Blue colour and G₁, G₂=Green colour
• UV screening of raw material