organisation of the immune system Flashcards
lymphocyte recirculation: summarise the re-circulation of lymphocytes, and explain its importance
what do naive lymphocytes enter
blood, peripheral lymphoid tissue (secondary lymphoid organs)
when do naive lymphocytes stop recirculating
until meet antigen and become activated, or die
how do lymphocytes enter lymph nodes after leaving circulation
via high endothelial venules
what secondary lymphoid organ do lymphocytes not enter after leaving circulation
spleen
important feature of high endothelial venules
specialised endothelium containing molecules involved in arresting lymphocyte
at which stage do lymphocytes roll along with weak affinity
selectin
what signals to a lymphocyte to have a higher affinity
gradient of chemokines (chemotaxis)
at which stage do lymphocytes enter with high affinity
integrin
what presents antigens to recirculating lymphocytes
dendritic cells (APC)
