antigen presentation and T lymphocytes

Question 1

what is the major histocompatability complex

Answer 1

group of tightly linked genes important in specific immune response

Question 2

what is the function of the major histocompatability complex

Answer 2

display peptide sample of IC contents at surface of all cells for possible immune cell recognition, marking “self” and indicating “health” of cells

Question 3

when does the major histocompatability complex present peptides

Answer 3

continuously, even in absence of infection

Question 4

what uses the major histocompatability complex to distinguish “self” and pathogenic peptides

Answer 4

T and B lymphocytes

Question 5

what MHC class are transplantation antigens

Answer 5

MHC class I

Question 6

what MHC class controls the ability to mount a regulatory antibody response

Answer 6

MHC class II

Question 7

where is MHC class I present

Answer 7

nearly all cells

Question 8

what 4 regions are present on the MHC class I molecule

Answer 8

peptide binding region, immunoglobulin like region, transmembrane region, cytoplasmic region

Question 9

MHC class I: what 2 sections make up the peptide binding region

Answer 9

a1, a2

Question 10

MHC class I: what 2 sections make up the immunoglonulin like region

Answer 10

B2-microglobulin, a3

Question 11

MHC class I: what are the domains similar to

Answer 11

antibodies

Question 12

MHC class I: how many transmembrane regions present

Answer 12

1

Question 13

MHC class I: length of accomodating peptide

Answer 13

shorter (8-10)

Question 14

MHC class I structure

Answer 14

diagram from MHC class I

Question 15

where is MHC class II present

Answer 15

“professional” antigen-presenting cells: dendritic cells, macrophages, B lymphocytes; codominant so MHC class I still present

Question 16

what 4 regions are present on the MHC class II molecule

Answer 16

peptide binding region, immunoglobulin like region, transmembrane region, cytoplasmic region

Question 17

MHC class II: what 2 sections make up the peptide binding region

Answer 17

a1, B1

Question 18

MHC class II: what 2 sections make up the immunoglonulin like region

Answer 18

a2, B2

Question 19

MHC class II: how many transmembrane regions present

Answer 19

2

Question 20

MHC class II: length of accomodating peptide

Answer 20

larger (>13)

Question 21

MHC class II structure

Answer 21

diagram from MHC class II

Question 22

diagram of peptide binding to MHC class I and class II

Answer 22

diagram; anchor residue and binding pocket

Question 23

what is the HLA

Answer 23

human leukocyte antigens - same as MHC in humans

Question 24

what chromosome is the HLA on

Answer 24

6

Question 25

what subsets of HLA class I are there

Answer 25

A, B, C (a and B2M)

Question 26

what subsets of HLA class II are there

Answer 26

DP, DQ, DR (a and B)

Question 27

whate regulates MHC class II cells

Answer 27

cytokines

Question 28

what is an MHC haplotype

Answer 28

group of MHC alleles linked in one chromosome

Question 29

in humans, how many MHC haplotypes are present

Answer 29

2 as diploid

Question 30

MHC polymorphism

Answer 30

diversity exists at population level, not within an individual; some combinations are more common than others