antigen presentation and T lymphocytes Flashcards
major histocompatibility complex (MHC) molecules: recall the outline structure, cellular distribution and functions of major histocompatibility complex (MHC) class I and class II molecules
what is the major histocompatability complex
group of tightly linked genes important in specific immune response
what is the function of the major histocompatability complex
display peptide sample of IC contents at surface of all cells for possible immune cell recognition, marking “self” and indicating “health” of cells
when does the major histocompatability complex present peptides
continuously, even in absence of infection
what uses the major histocompatability complex to distinguish “self” and pathogenic peptides
T and B lymphocytes
what MHC class are transplantation antigens
MHC class I
what MHC class controls the ability to mount a regulatory antibody response
MHC class II
where is MHC class I present
nearly all cells
what 4 regions are present on the MHC class I molecule
peptide binding region, immunoglobulin like region, transmembrane region, cytoplasmic region
MHC class I: what 2 sections make up the peptide binding region
a1, a2
MHC class I: what 2 sections make up the immunoglonulin like region
B2-microglobulin, a3
MHC class I: what are the domains similar to
antibodies
MHC class I: how many transmembrane regions present
1
MHC class I: length of accomodating peptide
shorter (8-10)
MHC class I structure
diagram from MHC class I
where is MHC class II present
“professional” antigen-presenting cells: dendritic cells, macrophages, B lymphocytes; codominant so MHC class I still present
what 4 regions are present on the MHC class II molecule
peptide binding region, immunoglobulin like region, transmembrane region, cytoplasmic region
MHC class II: what 2 sections make up the peptide binding region
a1, B1
MHC class II: what 2 sections make up the immunoglonulin like region
a2, B2
MHC class II: how many transmembrane regions present
2
MHC class II: length of accomodating peptide
larger (>13)
MHC class II structure
diagram from MHC class II
diagram of peptide binding to MHC class I and class II
diagram; anchor residue and binding pocket
what is the HLA
human leukocyte antigens - same as MHC in humans
what chromosome is the HLA on
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