antigen presentation and T lymphocytes Flashcards
antigen presenting cells (APCs): list examples of antigen presenting cells, explain the mechanisms by which they process and present antigens, and list their locations
definition of antigen presenting cell
cells that present processed antigen peptides to T lymphocytes in order to initiate an acquired immune response
examples of antigen presenting cells
dendritic cells, Langerhans cells, B lymphocytes and macrophages
where are dendritic cells present
widely spread
where are Langerhans cells present
all layers of epidermis
where are B lymphocytes and macrophages mainly present
blood and lymphoid tissue
where are endogenous antigens captured from
from in cytoplasm (generated due to normal function)
what are endogenous antigens presented via
MHC class I
what are endogenous antigens presented to
CD8 T cells
where are exogenous antigens captured from
outside cell
what are exogenous antigens presented via
MHC class II
what are exogenous antigens presented to
CD4 T cells
what mechanism does MHC class I use to present antigens
TAP (transporter associated with antigen processing) to transport peptides into ER
what mechanism does MHC class II use to present antigens
CLIP (class II associated invariant chain peptide)
