Oral Hypoglycaemics

Question 1

What is an example of Sulfonylurea

Answer 1

Chlorpropramide

Question 2

What is the action of sulfonyurea?

Answer 2

increase insulin secretion from B cells, in phase 1 spike

Question 3

What is the mechanism of action of sulfonyurea?

Answer 3

inhibit K(ATP) channels

Question 4

What is the action of Metformin?

Answer 4

Increase insulin sensitivity - increase glucose uptake, reduce glucose production, decrease carb absorption, reduce LDL level

Question 5

What is the side effect of metformin?

Answer 5

GI disturbances, diarrhoea, nasea, anorexia

Question 6

What is the contraindication of metformin?

Answer 6

Impaired renal function

Question 7

What is Thiazolidinediones similar to?

Answer 7

BIguanides (metformin)

Question 8

What is the action of acarbose?

Answer 8

it’s an alpha-glucosidase inhibitor, reduce starch absorption

Question 9

What is the adverse effect of acarbose?

Answer 9

flatulence/abdo discomfort

loose stools and abdo pain

Question 10

What is the contraindication of acarbose?

Answer 10

inflammatory bowel disease or cirrhosis

Question 11

What is the action of gliptin

Answer 11

increase native GLP-1 levels to increase insulin and decrease glucagon

Question 12

What is the action of Exenatide?

Answer 12

incretin mimetics and enhancers, regulating glucagon and insulin