Drugs for Obesity Flashcards
1
Q
What are the central peptides that increase feeding?
A
NPY
AGRP
2
Q
What are the central peptides that decrease feeding?
A
a-MSH
CART
3
Q
What’s the effect of leptin?
A
increase central energy usage and food intake
4
Q
What’s the mechanism of phentermine?
A
Increases NA/DA/5-HT, working in the same pathway as amphetamine in the CNS
5
Q
When can we indicate phentermine?
A
BMI > 30, only in the short term
6
Q
What’s the mechanism of Orlistat?
A
inhibits gastric and pancreatic lipases to decrease fat absorption
7
Q
What’s the indication of Orlistat?
A
BMI > 30 , 3 times per day with meal
8
Q
What must the orlistat be combined with?
A
low fat diet and vitamin supplementation
9
Q
What’s the adverse effect of orlistat?
A
explosive diarrhoea with high fat diet
