opioids abuse

Question 1

medication for the acute overdose

Answer 1

Naloxone: - opioid receptor antagonist (most potent at mu receptors)
- injectable and nasal spray

Question 2

what is the medication for the chronic abuse of opioids

Answer 2

Buprenorphine
- Mu receptor partial agonist
- long half-life of ~37 hours
- receptor binding affinity is 1000x that of morphine
- sublingual tablet
- often marketed as a combination product with naloxone

Question 3

how does Methadone work

Answer 3

• Mu receptor full agonist
• long half-life of ~7-65 hours
• the R- enantiomer has high activity but low affinity, compared
  with morphine
• marketed as a tablet, injectable, and oral solution

Question 4

how does Naltrexone work

Answer 4

• Mu receptor competitive antagonist
• medium half lives of 4 and 13 hours for parent and metabolite
• marketed as tablet

Question 5

give meds for the chronic abuse of the opioids

Answer 5

Naltrexone
Methadone
Buprenorphine
suboxone