amphetamine and cocaine

Question 1

what does amphetamine cause in the brain

Answer 1

monoamine release

Question 2

what does cocaine cause in the brain

Answer 2

inhibit monoamine reuptake

Question 3

what does addrerall contains of

Answer 3

contain dextroamphetamine (d-amphetamine) and levoamphetamine (l-amphetamine) salts in the ratio of 3:1

Question 4

what is the brand name of the dextroamphetamine and what is it for ?

Answer 4

Dexedrine// indicated for ADHD and for narcolepsy

Question 5

what is the narcolepsy

Answer 5

narcolepsy: - extreme daytime sleepiness
- involves loss of neurons expressing hypocretin/orexin
- various stimulants are prescribed for symptomatic treatment

Question 6

what is Goprelto

Answer 6

local anesthetic solution for local anesthetic of mucos membrane

Question 7

what is CREB

Answer 7

cAMP response element binding protein (CREB)

Question 8

what does the activation of CREB cause

Answer 8

activated CREB reduces the sensitivity to stimulant drugs (tolerance)

Question 9

explain ∆FosB activation

Answer 9

• activated ∆FosB is stable for weeks
• activated ∆FosB increases
  sensitivity to stimulant drugs and
  drug-taking, via positive
  reinforcement (dependence /
  addiction)
• selective for D1-containing neurons
  Nestler 2013. Dialogues Clin Neurosci. 2013;15:431-443.

Question 10

the last slide needs to be discuss by AI