Opioids Flashcards
Fentanyl: Class
Opioid agonist
Fentanyl: Use
Reduce pain
Postoperative analgesia
Decrease Somatic and Autonomic response
Fentanyl: Mechanism of Action
Binds to Mu1, Mu2, Kappa and delta receptors
Fentanyl: Dose
Induction: 1 mcg/kg
Infusion: 0.01 mcg/kg/min
Small dose Bolus: 25 mcg
Fentanyl: Pharmacokinetics
Absorption: IM, IV, epidural/intrathecal, transdermal, transmucosal
Onset: 2 minutes
Duration of Action: 30 minutes
Metabolism: Hepatic
Excretion: Feces and Urine
Fentanyl: Contraindications
Hypersensitivity
Severe Respiratory depression
Fentanyl: Considerations
Decreases ventilatory response to hypoxia and hypercapnia
Bradycardia
Decreased Gastric motility
Reduced Stress response
?Promote cancer cell proliferation
Hydromorphone / Dilaudid: Class
Opioid Agonist
Hydromorphone / Dilaudid: Use
Pain management
Hydromorphone / Dilaudid: Mechanism of Action
Binds to Mu1, Mu2, Kappa and delta receptors
Hydromorphone / Dilaudid: Dose
IV 0.2 mg Bolus
Hydromorphone / Dilaudid: Pharmacokinetics
Absorption: PO, IV, Epidural, Intrathecal
Onset: 15 minutes
Duration of Action: 4 hours
Metabolism: Hepatic
Excretion: Kidneys
Hydromorphone / Dilaudid: Contraindications
Severe Respiratory Suppression
Hypersensitivity
Hydromorphone / Dilaudid: Considerations
Decreases ventilatory response to hypoxia and hypercapnia
Bradycardia
Decreased Gastric motility
Reduced Stress response
?Promote cancer cell proliferation
Meperidine: Class
Opioid Agonist