Diuretics

Question 1

Furosemide: Class

Answer 1

Loop Diuretic

Question 2

Furosemide: Use

Answer 2

Heart Failure
Peripheral and Central Edema
Elevated ICP
Renal Failure

Question 3

Furosemide: Mechanism of Action

Answer 3

Inhibits reabsorption of Na, Cl, K in the thick ascending loop of Henle

Question 4

Furosemide: Dose

Answer 4

5mg titrate as needed

Question 5

Furosemide: Pharmacokinetics

Answer 5

Absorption: IV, PO

Onset: 5 minutes
Duration of Action: 2 hours

Metabolism: Hepatic

Elimination: Renal

Question 6

Furosemide: Contraindictions

Answer 6

Hypersensitivity
Hypotension
Severe Electrolyte abnormalities

Question 7

Furosemide: Considerations

Answer 7

Ototoxic
Can cause Hypotension
Potentiates NMBs

Question 8

Mannitol: Class

Answer 8

Osmotic Diuretic

Question 9

Mannitol: Use

Answer 9

Increased ICP
Renal Perfusion

Question 10

Mannitol: Mechanism of Action

Answer 10

Increase the osmolarity of plasma. Draws in fluid from ICF and ECF and out of the brain.
Draws fluids and Na, Cl, Bicarb into the urine while increasing urine output

Question 11

Mannitol: Dose

Answer 11

250 mg - 1 gram/kg over 30 - 60 minutes

Question 12

Mannitol: Pharmacokinetics

Answer 12

Absorption: IV

Onset: 15 minutes
Duration of Action: 3 hours

Metabolism: NOT METABOLIZED

Elimination: Renal

Question 13

Mannitol: Contraindications/ Consideration

Answer 13

Risk for hypovolemia
Electrolyte Abnormalities
Pulmonary Edema