Coagulants/Anticoagulants Flashcards
Heparin: Class
Anticoagulant
Heparin: Use
DVT prophylaxis
PE
Acute coronary syndrome
Heparin: Mechanism of Action
Forms a complex with antithrombin 3, increasing its activity 1,000 x’s
inhibits: Thrombin 2a and Factor 10a
Depresses: Factors 9a, 11a, 12a
Heparin: Dose
SQ: 5,000 units for DVT prophylaxis
Heparin: Pharmacokinetics
Absorption: IV, SQ
Onset: Rapid
Duration of Action: 6 hours
Metabolism: Hepatic
Elimination: Reticuloendothelial system
Heparin: Contraindications
Bleeding
History of HIT
Heparin: Considerations
Check PTT/ ACT levels
risk for bleeding & HIT
Protamine: Class
Heparin antidote
Protamine: Use
Reversal of heparin
Protamine: Mechanism of Action
Combines with heparin to form inactive compound with no anticoagulation effects
Protamine: Dose
1mg for every 100 units of heparin that was given
Protamine: Pharmacokinetics
Absorption: IV
Onset: 5 minutes
Duration of Action: 2 hours
Metabolism: Reticuloendothelial system
Elimination: Reticuloendothelial system
Protamine: Contraindications
Hypersensitivity
derived from salmon semen
Protamine: Considerations
1/2 life is shorter than Heparin’s. Rebound bleeding may occur
Releases histamine
Circ Collapse
Bronchoconstriction
Hypotension
Tranexamic Acid: Class
Antifibrinolytic agent
