Anticholinergics Flashcards
Atropine: Class
Antimuscarinic
Atropine: Use
Symptomatic bradycardia
Treatment of Cholinergic Syndrome
Paired with Edrophonium in NMB reversal
Atropine: Mechanism of Action
Competitive antagonist of acetylcholine at muscarinic receptors
Atropine: Dose
7 mcg/kg with Edrophonium
ACLS: 1mg Bolus, MAX 3 mg
Atropine: Pharmacokinetics
Absorption: IV, IM, PO
Onset: 1 minute
Duration of Action: 1 hour
Metabolism: Hepatic
Excretion: Renal and Hepatic
Atropine: Contraindictions
CAD
Pheochromocytoma
Hyperthyroidism
Myasthenia Gravis
Atropine: Considerations
Causes tachycardia
Sedation (crosses blood brain barrier)
Anticholinergic Syndrome
Glycopyrrolate: Class
Antimuscarinic
Glycopyrrolate: Use
Secretions
Bradycardia
Paired with Neostigmine
Glycopyrrolate: Mechanism of Action
Competitive antagonist of acetylcholine at muscarinic receptors
Glycopyrrolate: Dose
Non symptomatic bradycardia: 0.1 - 0.2 mg
With Neostigmine: 0.2 mg/ 1 mg of Neostigmine
Glycopyrrolate: Pharmacokinetics
Absorption: IV, IM, PO
Onset: 2 minutes
Duration of Action: 2 hours
Metabolism: Liver
Excretion: Renally, unchanged
Glycopyrrolate: Contraindications
CAD
Pheochromocytoma
Hyperthyroidism
Myasthenia Gravis
Glycopyrrolate: Considerations
Tachycardia
Scopolamine: Class
Antimuscarinic