Beta-Antagonists Flashcards

1
Q

Esmolol: Class

A

Selective Beta1 antagonist

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2
Q

Esmolol: Use

A

To prevent or minimize tachycardia or HTN from perioperative stimuli (Intubation, Surgical Stimulation, Emergence)

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3
Q

Esmolol: Mechanism of Action

A

Competitive antagonist of Beta1 receptors

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4
Q

Esmolol: Dose

A

Bolus: 0.5mg/kg or 10mg

Infusion: 50 mcg/kg/min
Can titrate q 5minutes to max dose 200mcg/kg/min

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5
Q

Esmolol: Pharmacokinetics

A

Absorption: IV

Onset: 1 minute
Duration of Action: 5 minutes

Metabolism: Rapid Hydrolysis by plasma esterase in RBCs

Elimination: Renal

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6
Q

Esmolol: Contraindications

A

Patients with:
Bradycardia
Hypotension
CHF
Bronchoconstriction

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7
Q

Esmolol: Considerations

A

Administration intra-operatively can help reduce the use of post-operative opioids

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8
Q

Labetalol: Class

A

Non-selective beta antagonist

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9
Q

Labetalol: Use

A

Used to treat Tachycardia and HTN

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10
Q

Labetalol: Mechanism of Action

A

Competitive antagonist of Beta1, Beta2, and Alpha1 receptors
Beta blockade to Alpha Blockade = 7:1

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11
Q

Labetalol: Dose

A

Bolus: 5 - 20 mg

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12
Q

Labetalol: Pharmacokinetics

A

Absorption: IV

Onset: 5 minutes
Duration of Action: 3 hours

Metabolism: Hepatic

Elimination: Hepatic and Renal

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13
Q

Labetalol: Contraindictions

A

Patients with:
Bradycardia
Hypotension
CHF
Asthma
COPD

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14
Q

Labetalol: Considerations

A

May cause:
LV failure
Orthostatic hypotension
Bronchospasm

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