Beta-Antagonists Flashcards
Esmolol: Class
Selective Beta1 antagonist
Esmolol: Use
To prevent or minimize tachycardia or HTN from perioperative stimuli (Intubation, Surgical Stimulation, Emergence)
Esmolol: Mechanism of Action
Competitive antagonist of Beta1 receptors
Esmolol: Dose
Bolus: 0.5mg/kg or 10mg
Infusion: 50 mcg/kg/min
Can titrate q 5minutes to max dose 200mcg/kg/min
Esmolol: Pharmacokinetics
Absorption: IV
Onset: 1 minute
Duration of Action: 5 minutes
Metabolism: Rapid Hydrolysis by plasma esterase in RBCs
Elimination: Renal
Esmolol: Contraindications
Patients with:
Bradycardia
Hypotension
CHF
Bronchoconstriction
Esmolol: Considerations
Administration intra-operatively can help reduce the use of post-operative opioids
Labetalol: Class
Non-selective beta antagonist
Labetalol: Use
Used to treat Tachycardia and HTN
Labetalol: Mechanism of Action
Competitive antagonist of Beta1, Beta2, and Alpha1 receptors
Beta blockade to Alpha Blockade = 7:1
Labetalol: Dose
Bolus: 5 - 20 mg
Labetalol: Pharmacokinetics
Absorption: IV
Onset: 5 minutes
Duration of Action: 3 hours
Metabolism: Hepatic
Elimination: Hepatic and Renal
Labetalol: Contraindictions
Patients with:
Bradycardia
Hypotension
CHF
Asthma
COPD
Labetalol: Considerations
May cause:
LV failure
Orthostatic hypotension
Bronchospasm