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7453 Neuro Test 4 > Opiate Cessation > Flashcards

Opiate Cessation Flashcards

1
Q

3 opioid cessation programs

A
  • 12 step programs
  • narcotics anonymous
  • mutual help programs-health systems
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2
Q

What is the antidote for opioid overdose?

A

naloxone

opioid antagonist

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3
Q

Naloxone is structurally similar to ___, but has no analgesic properties.

A

morphine

no abuse potential
not a controlle substance

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4
Q

Which type of opioid receptor does naloxone bind too?

A

Mu

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5
Q

Is naloxone an agonist or antagonist?

A

antagonist

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6
Q

Naloxone has no effect in the absence of opioids.

a. true
b. false

A

a. true

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7
Q

Which route of naloxone administration has fastest onset of action?

A

IV

IV: 2mins
Nasal: 8-10mins
IM: 2-5mins

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8
Q

Does naloxone have a PO formulation?

A

no

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9
Q

The naloxone profiled syringe is what concentration?

A

2mg/mL

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10
Q

How is naloxone profiled syringe administered?

A
  • 1mL in each nostril PRN

- inject 2mL IM in outer thigh PRN

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11
Q

What is the concentration of the naloxone vial?

A

0.4mg/mL

comes in 2 vials

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12
Q

How is naloxone vial administered?

A

inject 1mL in outer thigh PRN, repeat in 2 mins PRN

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13
Q

What is the concentration of the naloxone auto-injector?

A

2mg/0.4mL

or 0.4mg/0.4mL

comes as a two pack

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14
Q

How is the naloxone auto injector (Evzio) administered?

A

inject in outer thigh PRN, repeat in 2mins PRN

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15
Q

__ maintenance therapy is the cornerstone for opiate addiction.

A

methadone

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16
Q

R methadone binds to which receptor?

A

mu opiate

17
Q

S methadone binds to which receptor?

A

NMDA receptor

18
Q

Methadone is a substrate for efflux pump?

A

P-glycoprotein

19
Q

Methadone is primarily metabolized by what two CYPs?

A

3A4

2B6

20
Q

Methadone can cause what type of heart problem?

A

torsades de pointes

21
Q

Which CYP may be genetic tested for methadone?

A

2B6

22
Q

Which 2B6 allele is associated with higher concentrations?

A

2B611

23
Q

What is buprenorphine MOA?

A

partial mu opiate receptor agonist and kappa opiate antagonist

24
Q

Buprenorphine can be used alone as an alternative to methadone for opiate addiction.

a. true
b. false

A

a. true

25
Q

Naloxone has very low bioavailability.

a. true
b. false

A

a. true

< 10%

half life 1.1 hrs
glucuronidation

26
Q

What ratio of buprenorphine:naloxone (Suboxone) is FDA approved?

A

4:1

2mg: 0.5mg
8mg: 2mg

27
Q

The buprenorphine implant is better than sublingual formulation over longer periods of time.

a. true
b. false

A

a. true

can start on sublingual and switch to implant

28
Q

Which two opioids have combination formulations with naltrexone?

A
  • morphine

- oxycodone

29
Q

What is the time of onset for the therapeutic actions of naloxone given nasally?

A

8-10 mins

7453 Neuro Test 4 (9 decks)

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