Alcohol Cessation

Question 1

Definition of heavy drinking?

Answer 1

> 5 drinks on the same occasion on > 5 days/month

Question 2

Tolerance and withdrawal are associated with alcohol ___

dependence or abuse?

Answer 2

dependence

Question 3

Alcohol ___ is associated with impaired performance.

dependence or abuse?

Answer 3

abuse

Question 4

3 techniques for coping with cravings and urges for alcohol?

Answer 4

• delay technique
• distract technique
• urge surfing technique

Question 5

Counseling should be done every __ weeks.

Answer 5

2

Question 6

Initial treatment is __ months and can be indefinite

Answer 6

6

Question 7

3 FDA approved drugs for alcohol cessation?

Answer 7

• disulfiram
• acamprosate
• naltrexone

Question 8

Metabolites of disulfiram inhibit what enzyme?

Answer 8

aldehyde dehydrogenase

Question 9

Avoid what cessation drug in persons with severe hepatic impairment?

Answer 9

disulfiram

Question 10

Disulfiram enzyme inhibitions ___

reversible or irreversible?

Answer 10

irreversible

Question 11

Which cessation drug decreases cravings?

Answer 11

acamprosate

Question 12

which cessation drug is approved for alcohol dependence after detoxification and a focus on abstinence maintenance?

Answer 12

acamprosate

Question 13

Which cessation drug has no hepatic metabolism?

Answer 13

acamprosate

renal elimination

Question 14

Should acamprosate dose be decreased with renal impairment?

Answer 14

yes

linear PK

Question 15

Avoid acamprosate use with clearance of ___ L/hr

Answer 15

1.1

Question 16

What is main MOA of acamprosate?

Answer 16

antagonism of NMDA receptors

2nd is antagonism of opiate and noradrenergic receptors

Question 17

How many assessments for acamprosate?

Answer 17

10

every 4 weeks for first 12 weeks, then every 12 weeks

Question 18

Duration of acamprosate treatment?

Answer 18

96 weeks

Question 19

Which cessation med decreases cravings, and has an oral form and long acting injection form?

Answer 19

naltrexone

Question 20

There are no naltrexone dose adjustments with mild to moderate hepatic impairment.

a. true
b. false

Answer 20

a. true

Question 21

What two drugs reduce the craving for alcohol?

Answer 21

• acamprosate

- naltrexone