Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

7453 Neuro Test 4 > Anxiety Pharmacotherapy > Flashcards

Anxiety Pharmacotherapy Flashcards

1
Q

GAD 7 Item Questionare:

Mild score?

A

5-9

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

GAD 7 Item Questionare:

Moderate score?

A

10-14

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

GAD 7 Item Questionare:

Severe score?

A

15-21

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Most effective and safe drug class for RAPID relief of anxiety Sx?

A

benzos

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

5 first line drugs for GAD?

DEPSV

A 
D - duloxetine
E - escitalopram
P - paroxetine
S - sertraline
V - venlafaxine XR
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

First line drug class for panic disorder?

A

SSRIs

also venlafaxine XR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

5 first line drugs for social anxiety disorder?

EFPSV

A 
E - escitalopram
F - fluvoxamine CR
P - paroxetine
S - sertraline
V - venlafaxine XR
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What atypical antipsychotic is used for GAD?

A

quetiapine 150mg

quetiapine 150mg = paroxetine 20mg/day

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is used in Europe as a first line agent for GAD, but is off-label at best in the USA?

A

pregabalin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What benzo is FDA approved for panic disorder with or without agoraphobia.

A

alprazolam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

IM administration of which 2 benzos should be avoided?

A
  • diazepam
  • chlordiazepoxide

erratic absorption and painful

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which 2 benzos are glucuronidated?

A
  • lorazepam

- oxazepam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which benzo undergoes nitroreduction?

A

clonazepam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

__ is a prodrug converted to desmethyldiazepam in the GI tract under acidic pH.

A

clorazepate

watch out for antacid use!!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

___ is a physiologic occurrence that manifests when the drug is abruptly d/c.

A

dependence

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Time to onset of withdrawal Sx for short acting benzos?

A

24-48hrs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Time to onset of withdrawal Sx for long-acting benzos?

A

3-8 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Can buspirone be used in pts with substance abuse history?

A

yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

How long until max benefit of buspirone?

A

4-6 weeks

increase dose by 5mg every 2-3 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Which SSRI is not a preferred agent for pregnant pts?

A

paroxetine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What class of anxiety drugs are associated with cleft lip and palate in babies?

A

benzos

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Benzos should be avoided in which trimester?

A

first

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Benzo use in which trimester can cause sedation, withdrawal, and floppy baby syndrome?

A

third

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Which two benzos can cause neonatal withdrawal Sx?

A
  • lorazepam

- alprazolam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Pts with Hx of substance/alcohol abuse should not use benzos.

a. true
b. false

A

a. true

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Which TCA can work in 4 weeks for panic disorder attacks, and has max improvement in 8-12 weeks for anti phobic?

A

imipramine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

How long is panic disorder acute phase Tx?

A

1-3 months

therapy altered if no response in 6-8 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

How long is panic disorder maintenance Tx?

A

12-24 months

drug d/c over 4-6 months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

How long is the continuation phase of social anxiety disorder?

A

3-6 months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Are TCAs effective for social anxiety disorder?

A

no

SSRIs and SNRIs equally effective

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Which 2 SSRIs are FDA approved for panic disorder?

A
  • sertraline

- paroxetine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Which 2 benzos are FDA approved for panic disorder?

A
  • clonazepam

- alprazolam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

What drug class is last line for children with social anxiety disorder?

A

benzos

34
Q

Is gabapentin effective for social anxiety disorder?

A

yes

35
Q

What is the minimum amount of time needed for treatment with a SSRI for a pt with panic disorder who responds to a SSRI agent?

A

minimum of 12 months

can be up to 24 months

36
Q

What two SSRI agents are FDA approved for acute PTSD?

A
  • sertraline

- paroxetine

37
Q

What dose-dependent AE is associated with clomipramine?

A

seizures

38
Q

Which agent would you recommend for a child age 10 yrs for OCD Tx, fluvoxamine or clomipramine?

A

fluvoxamine

39
Q

2 goals of PTSD therapy?

A
  • decrease core Sx

- improve QOL

40
Q

Which SSRI is FDA approved for long term PTSD Tx?

A

sertraline

41
Q

Are benzos effective for treating PTSD?

A

no

42
Q

Which SSRI shows no dose-dependent improvement of PTSD?

A

paroxetine

43
Q

Which class of meds decreases numbing PTSD symptoms?

A

SSRIs

44
Q

What medication is effective for PTSD in global ratings with doses of 45mg/day?

A

mirtazapine

45
Q

Which med is effective for PTSD avoidance/numbness and hyperarousal?

A

venlafaxine

46
Q

What alpha 1 adrenergic antagonist is useful in some PTSD pts to decrease nightmares and sleep disturbance?

A

prazosin

47
Q

Sertraline should be increased at what rate for PTSD?

A

50mg/week

48
Q

Paroxetine should be increased at what rate for PTSD?

A

10mg/week

49
Q

Dosing/administration of SSRIs for PTSD when slow response wanted?

A

start after 3-4 weeks at low doses

8-12 weeks needed to assess response

50
Q

What drug class may be helpful for PTSD explosiveness, intrusive thoughts, aggression, and flashbacks?

A

atypical antipsychotics

51
Q

Is risperidone effective for add on therapy in PTSD?

A

total effects questionable

52
Q

How often are PTSD pts seen?

A

weekly for 1 month, then every other week for the second month

months 3-6: see monthly
months 6-12: see every other month

53
Q

___ % reduction of Sx is considered remission for PTSD.

A

70

54
Q

SSRIs should be used for __ to __ weeks for PTSD initially.

A

8, 12

4-6 weeks at max dose

55
Q

5 FDA approved drugs for OCD?

A
  • clomipramine
  • fluvoxamine
  • fluoxetine
  • paroxetine
  • sertraline
56
Q

What rating scale is used by clinicians for OCD?

A

YBOCS

57
Q

If one SSRI is ineffective for OCD, another should not be attempted.

a. true
b. false

A

b. false

58
Q

OCD Tx resistance is failure to decrease __ % from baseline YBOCS scores.

A

25

59
Q

Which SSRI PK is not altered in renal failure pts?

A

sertraline

60
Q

Do OCD pts with renal failure need clomipramine dosage adjustments?

A

no

be careful dosing anyway

61
Q

Which OCD SSRI has increased Cpss in renally impaired pts?

A

paroxetine

62
Q

What should be used first for OCD in pregnancy?

A

CBT alone

63
Q

What SSRI is safest for OCD in pregnancy?

A

fluoxetine

avoid clomipramine

64
Q

What is an adequate Tx period for OCD?

A

10-12 weeks

65
Q

What should be tried next if CBT or SSRI for OCD do not provide adequate response?

A

combo therapy with CBT + SSRI should be tried before augmentation with another agent

66
Q

What is max dose of citalopram for OCD?

A

40mg to prevent QTc prolongation

67
Q

What should pts over 40yrs old get before clomipramine Tx?

A

ECG

68
Q

Why should WBC with differential be gotten immediately if fever/sore throat with clomipramine?

A

possible agranulocytosis

69
Q

How long for tolerance to clomipramine AEs?

A

2 weeks

70
Q

Do TCAs or clomipramine cause more seizures?

A

clomipramine

OCD Tx

71
Q

Is venlafaxine FDA approved for OCD?

A

no

can be used, but not approved

72
Q

How long should pt be at max dose for OCD Tx before switching?

A

8-13 weeks

therapy for 1-2 years

73
Q

How should drugs be tapered for OCD?

A

10-25% every 1-2 months

74
Q

How often should visits occur for OCD?

A

monthly for 3-6 months

75
Q

Which age group more commonly has trichotillomania?

A

> 18yrs

76
Q

Trichotillomania:

What type is minimal thinning that can be camouflaged with hair styling techniques?

A

type 1

77
Q

Trichotillomania:

Which type is characterized by decreased volume and noticeable widening of the midline part?

A

type 2

78
Q

Trichotillomania:

Which type is characterized by diffuse thinking, with see through appearance on top of scalp?

A

type 3

79
Q

Most pts with trichotillomania are unemployed females > 18yrs old.

a. true
b. false

A

b. false

employed, > 18yr old female

80
Q

What is the most common age range for onset of trichotillomania?

A

6-12yrs old

7453 Neuro Test 4 (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions