Ophthomology Flashcards
What are the five required tools for ophthomology?
Good light source, schirmer tear test, fluorescein, tonometry, ophthalmoscope
What do you need to know about your patient before even seeing it?
Signalment, history,
What cranial nerves might be affected with Cavernous Sinus syndrome?
CN III, IV, V, VI
Which species, cat or dog, has a shorter orbital ligament?
Cat, so it has more protection from the skull
What type of dogs are most susceptible to ocular disease via damage to the orbital ligament, and why?
Brachiocephalic dogs. The orbital ligament is much shallower
What are some signs you will see with exophthalmos?
3rd eyelid protrusion, facial swelling, soft palate bulging, pain when opening mouth, fever
What are two most common causes of exophthalmos?
orbital neoplasia, orbital cellulitis/abscess
T/F: orbital neoplasia is often benign
False, malignant, slowly progressive, non-painful
T/F: orbital abscesses are often painful
True. acute onset
What are the two approaches to treat orbital neoplasia?
Globe sparing (radiation, exploration, chemo)
Globe removal (enucleation, exenteration)
What are the two approaches to treat orbital abscesses?
NSAIDs + antibiotics
Surgical intervention
What are some clinical signs seen with enophthalmos?
facial muscular loss, third eyelid protrusion, entropion (eyelid facing inward)
What are the three common mechanisms of enophthalmos?
Orbital volume imbalances (dehydration, emaciation, disease)
Active globe retraction (muscle retraction)
Passive globe retraction (horner’s syndrome, damage to sympathetic nerves)
What is phthisis bulbi?
an acquired shrunken globe, from severe or chronic inflammation
What is strabismus?
deviation of one or both eyes where both eyes are not directing the same object
How can strabismus be acquired?
dysfunction of any rectus muscle of the eye. CN III (DVM), CN IV, CN VI
What is proptosis?
Protrusion of the eye, where the eyelids are cause behind the equator of the globe.
What is a commonly better prognosis for proptosis?
brachycephalic dogs, a few torn extraocular muscles torn, positive PLRs
What is a commonly poor prognosis for proptosis?
Cats, dolichocephalic dogs, >3 extraocular muscles torn, hyphema, orbital fracture, ruptured eye
T/F: Dogs with proptosis have a low chance of regaining their sight.
True. 75-80% will be blinded in that eye
How would you treat proptosis?
Temporary tarsorrhaphy (suturing eyelids closed)
T/F: Proptosis can lead to strabismus.
True. medial rectus is the shortest muscle and is easily torn.
What’s another word for Meibomian glands?
Tarsal glands
What are the four layers of the eyelid?
Skin, Muscle, Tarsus, Conjunctiva
What are the three muscles that are relevant for eyelid movement?
Orbicularis oculi (closes like zipper)
Levator palpebrae superioris, Muller’s muscle (opens eyelid)
What is ptosis?
drooping of the eyelid
What is lagophthalmos?
Incomplete eyelid closure and globe coverage
What is the function of the tarsus of the eye?
It is the fibrous and glandular layer of the eyelid. Supports the Meibomian glands.
What do surgeons use the tarsus for?
It is the holding layer for eyelid closure
T/F: The bulbar conjunctiva is usually slightly more hyperemic than the palpebral conjunctiva.
False. Palpebral is more hyperemic than the bulbar.
What are the two types of entropion?
Anatomic, were eyelids are conformed to the eye.
Blepharospasm associated, where pain leads to retraction of the eyelid.
You see a 5 month old puppy with anatomic entropion. What are some options of treatment?
Temporary correction via sutures. Leave alone and it may fix itself in a few months
What can acquired anatomic entropion lead to?
Enophthalmos, and blepharospasm (vicious cycle)
How can you differentiate between anatomic and blepharospasm entropion?
Local anesthetic in eye (proparacaine) will relieve the pain-induced blepharospasm
What are some temporary corrections for entropion?
Viscous lubrication, eyelid tacking, partial temporary tarsorrhaphy
What is the permanent correction for entropion?
Modified Hotz-Celsus
What are the common causes of ectropion?
iatrogenic (too much entropion correction)
hereditary
T/F: ectropion requires a lot more treatment than entropion
False.
What is the surgical procedure used for ectropion?
Lateral eyelid wedge excision
What are the 4 common causes of lagophthalmos?
- ) Breed
- ) Exophthalmos
- ) Buphthalmos
- ) CN V/CN VII dysfunction
What are the ocular signs seen with sympathetic denervation?
(Horner’s syndrome)
Miosis, enophthalmos, protrusion of the 3rd eyelid, ptosis
How does Horner’s syndrome cause ptosis and miosis?
Lack of tone in the Muller’s upper eyelid muscle and pupillary dilator muscle respectively.
Most commonly, how do you approach treatment for Horner’s?
You don’t. It’s typically idiopathic and resolves itself
Does Horner’s usually affect post- or pre-ganglionic nerves?
Post-ganglionic.
How do you diagnose Horner’s?
Phenylephrine 1% into the eye.
Normal - 60 minutes to dilation
Post-ganglionic - 20 minutes
Pre-ganglionic - 40 minutes
What are the three abnormal hair conditions that have clinical significance?
- ) Trichiasis
- ) Disctichiasis
- ) Ectopic Cilia
What is trichiasis?
Normal hairs reach into the eye and cause irritation to the surface
What is a surgical treatment used on brachycephalic breeds with trichiasis?
Medial canthoplasty
What is distichia?
Cilia emerge from the Meibomian glands
When would you want to treat for distichia?
If it is causing corneal/conjunctival disease
What are the treatment options for distichia?
Cryotherapy. Pluck the hair, then freeze
What is something to be cautious about with cryotherapy?
Eyelis depigmentation and necrosis
Which of the eye hair abnormalities leads to severe pain and corneal disease, that also waxes and wanes through the hair life cycle?
Ectopic cilia.
How would you treat ectopic cilia?
Cryotherapy
T/F: Canine eyelid tumors are typically more malignant than feline eyelid tumors.
False.
What is the most common eyelid tumor in dogs?
Meibomian gland adenoma/melanocytoma
What is the most common eyelid tumor in cats?
SCC
What are the three questions to ask yourself when dealing with canine eyelid tumors?
Is it causing irritation? How big is it? Where is it?
How would you treat a canine eyelid tumor? (two methods)
Debulk and cryotherapy
Complete excision
What are four key concepts of closing the eyelid during surgery?
- Limit the debridement
- closure must be a perfect figure 8 suture pattern
- avoid full thickness bites
- tarsus is the holding layer
What is blepharitis?
Inflammation of the eyelids
What is a chalazion?
A type of blepharitis due to enlargement of the meibomian gland from a blockage of the duct
How do you treat a chalazion?
Warm compress, surgical draining via incision, topical antibiotics
What is a hordeolum? Meibomianitis?
Bacterial infection of a meibomian gland. Meibomianitis involves multiple glands.
How would you treat a bacterial blepharitis case?
Systemic antibiotics, topical antibiotics/steroid, warm compress
How do you diagnose immune-mediated blepharitis?
Biopsy and cytology
T/F: Cherry eye is not commonly an emergency nor painful.
True
What does the third eyelid cartilage do?
Gives structure and shape, and supports the third eyelid gland.
What is another way of saying ‘prolapsed gland of the 3rd eyelid’?
Cherry eye.
When is the only indication to completely remove the third eyelid gland?
Neoplasia.
What are the two treatments for cherry eye?
Morgan pocket technique, orbital tacking.
What is one important thing to think about when suturing up a cherry eye with the morgan pocket technique?
Do not fully close the incision. The gland still needs to drain its secretions, or a cyst may form
How can you treat eversion/scrolling of the third eyelid?
Excise the deformed cartilage, thermal cautery to kink/contract the cartilage.
What are some normal ocular conjunctival variations between each patient?
Encircling of the third eyelid (more some than others
Prominent episcleral vessels
Pigment
Where are the lymphoid follicles of the eye typically located?
On the bulbar surface of the third eyelid.
Where are the episceral vessels in relation to the conjunctival vessels?
They are deeper into the eye, also larger
What does conjunctival hyperemia suggest about the eye?
There is some superficial irritation (conjunctivitis, corneal ulcers, KCS)
What does episcleral injection suggest about the eye?
Deeper inflammation and congestion than conjuncival hyperemia.
T/F: You do not often see both hyperemia and episcleral injection at the same time
False. Commonly present together
What is the most common cause of conjunctivitis?
Keratoconjunctivitis sicca
What are some clinical signs of a patient with allergic conjunctivitis?
Blepharospasm, epiphora, mucoid discharge, hyperemia, lymphoid follicles
T/F: Allergic and viral conjunctivitia have the same clinical signs
True
How do you treat primary conjunctivitis?
Treat underlying cause, topical anti-inflammatory (NSAID, steroid), Optimmune (cyclosporine)
What are the most common causes of feline conjunctivitis?
Herpes, eosinophilic keratoconjunctivitis, chlamydia, mycoplasma, calicivirus
How many cats (percentage) are exposed to FHV-1?
100%
How many cats (percentage) are persistently infected by FHV-1?
80%
What are the two forms of herpes in cats?
Primary disease, then recrudescence (break out).
T/F: It is easy to diagnose and treat FHV-1
False! It’s hard!
What do you see with kittens that are infected with FHV-1?
Upper respiratory tract infection, blepharospasm, epiphora, and mucoid discharge
What cranial nerve is affected by FHV-1?
Cranial nerve V - trigeminal
How can latent FHV-1 be reactivated?
environmental stress
corticosteroids
What are some specific clinical signs for FHV-1?
Hyperemia and symblepharon (permanent adhesion between conjunctiva and cornea)
What corneal lesion is pathopneumonic for FHV-1?
Dendritic corneal ulceration (can see with fluorescein stain)
What disease should you consider when you see a cat with conjunctivitis and presence/history of keratitis?
FHV-1
How do you treat ocular FHV-1?
Antivirals - topical cidofovir, oral famciclovir
What do you see with feline eosinophilic keratoconjunctivitis?
Raised yellow/white plaques on the corneal/conjunctival areas
How do you diagnose feline eosinophilic keratoconjunctivitis?
Cytology. Just ONE eosinophils is diagnostic
How do you treat feline eosinophilic keratoconjunctivitis?
Immunomodulation (cyclosporine), anti-inflammatory, antiviral
What do you typically see with chlamydial conjunctivitis?
Chemosis!
T/F: Chlamydia does not commonly cause ulceration on the eye
True
How do you diagnose chlamydial/mycoplasma conjunctivitis?
PCR, cytology, rule outs of others
How do you treat chlamydial/mycoplasma conjunctivitis?
intracellular antibiotics (tetracycline, macrolides)
What is pathopneumonic for calicivirus conjunctivitis?
Oral ulcerations
Because definitive diagnosis is difficult, how would you treat feline conjunctivitis?
Give antibiotics first, then if it does not work, lean towards potential herpes virus -> antiviral
What are the three layers of the lacrimal system?
Lipid, aqueous, mucinous
What is the function of the lacrimal system?
Nourish, cleanse, protection of the ocular surface
Define quantitative keratoconjunctivitis.
Superficial corneal and conjunctival inflammation with low measurement of tear production (via Schirmer tear test)
What is the most common cause of quantitative KCS?
Immune-mediated destruction of the lacrimal tissue.
If the patient has quantitative KCS and a dry nose, what would your diagnosis be?
Parasympathetic nerve lesion of CN VII
What types of breeds are at most risk of KCS?
small, toy breeds
What are the clinical signs of KCS?
mucoid and mucopurulent discharge (from overproduction mucous from goblet cells with absence of aqueous layer), keratitis (superficial corneal vessels)
How do you treat KCS?
Cyclosporine (immunomodulator)
What do can you use to treat KCS if cyclosporine does not work?
Tacrolimus
What are the four objectives of KCS treatment?
Replace the tears
Stimulate more tears
Anti-inflammatory
Anti-biotics
What is the pathophysiology of neurogenic KCS?
Loss of parasympathetic innervation to the lacrimal gland and ipsilateral nostril (dry nose)
How would you treat neurogenic KCS?
pilocarpine (stimulates PNS)
What is the pathophysiology of canine distemper KCS?
viral destruction of the lacrimal glandular epithelium. Severe!
How would you surgically treat KCS?
Parotid duct transposition, use of saliva to replace tears. Test saliva pH
What produces the lipids of the outermost layer of the lacrimal system?
Meibomian glands
Define qualitative KCS.
superficial KCS with normal Schirmer Tear test results
What is the innermost layer of the lacrimal system?
Mucin layer.
What test can you use to test for mucin deficiency?
Tear Film Breakup Time (TFBUT). See how long it takes for fluorescein stain to break up on ocular surface. (Normal = 20 seconds)
What do you see you corneal fibrosis, and what causes it?
A whitish hazy appearance on the cornea, caused by qualitative KCS.
How do you treat qualitative KCS?
Replace the tears with (artificial tears), reduce inflammation (cyclosporine)
What are two things that lead to epiphora?
Poor drainage, blockage
What is the Jones test?
Tests presence of the nasolacrimal duct system
What is imperforate puntum?
When the punctal opening of the nasolacrimal duct is closed. Need surgical opening
What is a nasolacrimal disease and how can you treat it?
Dacryocystitis, treat with dacryocystotomy
What are the five most common categories of ulcerative keratitis?
Superficial uncomplicated ulcers, canine indolent ulceration, deep corneal ulcers, descemetoceles, perforations
What is the limbus?
Junction between cornea and sclera