Dermatology Flashcards
What is Eosinophilic granuloma complex?
A skin condition with a spectrum of patterns on the skin leading to a variety of disease proceses
What are the three presentations of EGC?
- ) Indolent ulcers
- ) Eosinophilic plaques
- ) Collagenolytic granuloma
What are some causes of EGC?
Allergies - fleas, food
Infectious - parasites, bacteria,
Trauma
Genetics
What do indolent ulcers look like?
Well-circumscribed, proliferative inflammatory lesions on the LIP.
T/F: Indolent ulcers are non-painful and non-pruritic.
True
What do eosinophilic plaques look like?
Well circumscribed, red-yellow, ulcerated edematous on the inguinal area, abdomen, and thighs
T/F: Eosinophilic plaques are non-pruritic.
False. Intensely pruritic
What do collagenolytic granulomas look like?
Well circumscribed, nodular and firm yellow-pink lesions on the chin or limbs
T/F: Collagenolytic granulomas are non-painful and non-pruritic.
True
Where are atypical eosinphilic granulomas usually seen?
On the nose or ears.
How do you diagnose EG?
Cytology, histo, culture
How do you treat EGC?
strict parasitic control, steroids, immunomodulators, potentially surgery
How do you treat feline acne?
Treat the secondary infection and give human acne meds - benzoyl peroxide
What are the infectious causes of feline leprosy?
Nocardia, actinomyces, mycobacterium, dermatomycoses
What are the CxS of feline leprosy?
Nodules that burst and drain
How do you diagnose feline leprosy?
full skin exam, biopsy
T/F: Immune-mediated skin disorders are rare skin conditions
True. 1.4% of skin disorders
How do you diagnose immune-mediated skin disorders?
Histopathology with multiple biopsies
How do you treat immune-mediated skin disorders
Immunosuppressive drugs like steroids and cyclosporine
What is acantholysis?
The loss of intracellular connections between keratinocytes
T/F: Pemphigus erythematosus is benign
True
What is a potential aggravator of pemphigus erythematosus?
UV light
What might you see with a dog with pemphigus erythematosus?
Erythema, dermatitis on face and ears
Oozing crusts, scales, alopecia, erosion, epidermal collarette
Depigmentation on NOSE
How can you treat pemphigus erythematosus?
Avoid the sun, topical steroids/immunosuppressants
What is the most common immune-mediated skin condition?
Pemphigus foliaceus
What antigen is affected with pemphigus foliaceus?
desmoglein 1
What are the CxS of pemphigus foliaceus?
Pustular dermatitis, crusting on feet, face and ears
Nasal depigmentation
What antigen is affected with pemphigus vulgaris?
Desmoglein 3
What CxS will be seen with pemphigus vulgaris?
Erosions and ulcers on the oral cavity, mucocutaneous junctions, and skin (groin)
T/F: Prognosis for pemphigus vulgaris is typically poor
True
How could you treat pemphigus vulgaris?
High dose of prednisone and azathioprine
Chlorambucil for cats
What very rare condition forms autiantibodies against antigens of the basal cell hemidesmosomes of the skin and mucosa?
Bullous pemphigoid
What CxS will you see with bullous pemphigoid?
subepidermal vesicles and cutaneous lesions on the groin and in the mouth
Exposure to what aggravates discoid lupus erythematosus?
UV light exposure
What types of immune cells predominate with DLE?
T-helper cells activated from damage to keratinocytes
What are the CxS wth DLE?
depigmentation, erythema, scaling of nose leading to erosions, ulcers, and crusts
How can you diagnose DLE?
histopathology
How do you treat DLE?
avoid sun, vitamin E, corticosteroids
T/F: Etiology of systemic lupus erythematosus is from viruses
True, but is multifactorial and also comes from genetics, immune disorders, UV light
what CxS will you see on dogs with SLE?
Fever, polyarthritis, proteinuria
skin conditions - alopecia, erythema
What effects can cutaneous adverse drugs reactions cause?
Alopecia, purpura, poor wound healing, hyperpigmentation, pruritis
What CxS do you see with erythema multiforme?
Acute onset of macules and elevated papules, urticarial plaques
Where do you normally see the lesions of erythema multiforme?
Ventrum and groin
What are the causes of toxic epidermal necrolysis?
Drugs, flea dips
What CxS are there with toxic epidermal necrolysis?
Multifocal or generalized vesiculobullous disease
How do you diagnose TEN?
full thickness biopsy of affected skin
What parts of the body does vasculitis usually affect?
Extremities
How can you treat vasculitis?
Treat underlying disease, pentoxifylline, immunosuppressive/modulary drugs
