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Drugs > Ondansetron > Flashcards

Ondansetron Flashcards

1
Q

What is the MOA of ondansetron?

A

Antagonises peripheral and central 5-HT3 receptors

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2
Q

What is the absorption/distribution of ondansetron?

A
  • well absorbed orally
  • oral bioavailability 60%
  • protein bound 75%
  • half life 3hrs
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3
Q

What are the GI SEs of ondansetron?

A

Constipation

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4
Q

What are the CNS SEs of ondansetron?

A

Headache

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5
Q

What are the CVS SEs of ondansetron?

A
  • bradycardia
  • flushing
  • caution in patients wirh risk factors for prolonged QT interval/cardiac arrhythmias
  • dose-dependent prolongation of QT interval & cardiac arrhythmias including torsades
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6
Q

What is the metabolism and excretion of ondansetron?

A
  • hepatic metabolism
  • decrease dose in liver failure
  • excreted in urine
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7
Q

What is the dose of ondansetron?

A

4-8mg 8hrly (adult)

100 mcg/kg 8hrly (children > 2yrs)

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8
Q
A
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