Glycopyrrolate Flashcards

1
Q

What are the uses of glycopyrrolate?

A
  • premed to decrease secretions
  • to attenuate effects of anticholinesterases (eg when given to reverse non-depolarising muscle relaxants)
  • bradycardia
  • hyperhydrosis
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2
Q

What are the CVS effects of glycopyrrolate?

A
  • tachycardia
  • effect lasts 2-3hrs
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3
Q

What are the resp effects of glycopyrrolate?

A
  • bronchodilatation
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4
Q

What are the CNS effects of glycopyrrolate?

A
  • doesn’t cross BBB
  • causes headache and sedation
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5
Q

What is glycopyrrolate?

A
  • synthetic quaternary amine
    • carries a permanent charge on the N2 atom - therefore less lipid soluble
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6
Q

What is the dose of glycopyrrolate?

A

100-200mcg titrated to effect

Up to 600mcg

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7
Q

What are the GI effects of glycopyrrolate?

A

Antisialagogue

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8
Q

What are the metabolic effects of glycopyrrolate?

A

inhibits sweating

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9
Q

What are the antimuscarinic effects of glycopyrrolate?

A
  • dry mouth
  • urinary retention
  • blurred vision
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10
Q

What is the absorption/distribution of glycopyrrolate?

A
  • Poor oral absorption
    • oral bioavailibility 5%
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11
Q

What is the MOA of glycopyrrolate?

A
  • competitive antagonist at muscarinic receptors
    • does not cross BBB
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12
Q

What is the metabolism of glycopyrrolate?

A
  • minimal metabolism
  • excreted unchanged in urine
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13
Q
A
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