Glycopyrrolate

Question 1

What are the uses of glycopyrrolate?

Answer 1

• premed to decrease secretions
• to attenuate effects of anticholinesterases (eg when given to reverse non-depolarising muscle relaxants)
• bradycardia
• hyperhydrosis

Question 2

What are the CVS effects of glycopyrrolate?

Answer 2

• tachycardia
• effect lasts 2-3hrs

Question 3

What are the resp effects of glycopyrrolate?

Answer 3

• bronchodilatation

Question 4

What are the CNS effects of glycopyrrolate?

Answer 4

• doesn’t cross BBB
• causes headache and sedation

Question 5

What is glycopyrrolate?

Answer 5

• synthetic quaternary amine
  
  • carries a permanent charge on the N2 atom - therefore less lipid soluble

Question 6

What is the dose of glycopyrrolate?

Answer 6

100-200mcg titrated to effect

Up to 600mcg

Question 7

What are the GI effects of glycopyrrolate?

Answer 7

Antisialagogue

Question 8

What are the metabolic effects of glycopyrrolate?

Answer 8

inhibits sweating

Question 9

What are the antimuscarinic effects of glycopyrrolate?

Answer 9

• dry mouth
• urinary retention
• blurred vision

Question 10

What is the absorption/distribution of glycopyrrolate?

Answer 10

• Poor oral absorption
  
  • oral bioavailibility 5%

Question 11

What is the MOA of glycopyrrolate?

Answer 11

• competitive antagonist at muscarinic receptors
  
  • does not cross BBB

Question 12

What is the metabolism of glycopyrrolate?

Answer 12

• minimal metabolism
• excreted unchanged in urine