Glycopyrrolate Flashcards
1
Q
What are the uses of glycopyrrolate?
A
- premed to decrease secretions
- to attenuate effects of anticholinesterases (eg when given to reverse non-depolarising muscle relaxants)
- bradycardia
- hyperhydrosis
2
Q
What are the CVS effects of glycopyrrolate?
A
- tachycardia
- effect lasts 2-3hrs
3
Q
What are the resp effects of glycopyrrolate?
A
- bronchodilatation
4
Q
What are the CNS effects of glycopyrrolate?
A
- doesn’t cross BBB
- causes headache and sedation
5
Q
What is glycopyrrolate?
A
- synthetic quaternary amine
- carries a permanent charge on the N2 atom - therefore less lipid soluble
6
Q
What is the dose of glycopyrrolate?
A
100-200mcg titrated to effect
Up to 600mcg
7
Q
What are the GI effects of glycopyrrolate?
A
Antisialagogue
8
Q
What are the metabolic effects of glycopyrrolate?
A
inhibits sweating
9
Q
What are the antimuscarinic effects of glycopyrrolate?
A
- dry mouth
- urinary retention
- blurred vision
10
Q
What is the absorption/distribution of glycopyrrolate?
A
- Poor oral absorption
- oral bioavailibility 5%
11
Q
What is the MOA of glycopyrrolate?
A
- competitive antagonist at muscarinic receptors
- does not cross BBB
12
Q
What is the metabolism of glycopyrrolate?
A
- minimal metabolism
- excreted unchanged in urine
13
Q
A